Development and Validation of Computer Spreadsheet Used to Calculate Dissolution Profiles without Media Replacement

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Field Value
 
Title Development and Validation of Computer Spreadsheet Used to Calculate Dissolution Profiles without Media Replacement
 
Creator Abu Reid, Imad Osman
 
Subject Pharmaceutical Chemistry; Analysis
Spreadsheet; Dissolution profiles calculation without media replacement
 
Description Calculations carried out to generate dissolution profile data are complicated and subject to error to be performed manually, moreover and due to the repetitive nature of the dissolution testing experiments it is necessary to create a validated spreadsheet to replace and overcome the problems associated with manual calculations. A simple, user friendly spreadsheet was written to calculate dissolution profiles for a dissolution experiment where the volume of the dissolution medium for the vessel varies with time as the removed dissolution medium is not replaced with fresh one at each time point. The calculations of the spreadsheet were validated against manual calculations using a hand-held calculator; the results of the two methods were found to be comparable. The developed spreadsheet can be easily adapted for use in regulated environment after activating the security features embedded in Microsoft Excel software such as formula hiding, cell block and password protection.
 
Publisher International Journal of Advances in Pharmaceutical Analysis
 
Contributor
 
Date 2017-04-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Experimental
 
Format application/pdf
 
Identifier http://ssjournals.com/index.php/ijapa/article/view/4082
10.7439/ijapa.v7i1.4082
 
Source International Journal of Advances in Pharmaceutical Analysis; Vol 7, No 1 (2017): Jan-Mar; 06-09
2277-9353
 
Language eng
 
Relation http://ssjournals.com/index.php/ijapa/article/view/4082/2750
 
Rights Copyright (c) 2017 International Journal of Advances in Pharmaceutical Analysis
http://creativecommons.org/licenses/by/4.0
 

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