Vibrational Dynamics of 2-[3-(p-flourobenzoyl) Propyl]-1,2,3,4,6,7,12,12, a-octahydropyrazino[2′,1&prime:6,1] Pyrido [3,4-b] Indole [centbutindole]: A Potent Nuroleptic Drug

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Title Vibrational Dynamics of 2-[3-(p-flourobenzoyl) Propyl]-1,2,3,4,6,7,12,12, a-octahydropyrazino[2′,1&prime:6,1] Pyrido [3,4-b] Indole [centbutindole]: A Potent Nuroleptic Drug
 
Creator Singh, D. B.

Shukla, V. N.
Kumar, Vikash
Gupta, Pragya
 
Subject Vibrational frequencies, FITR spectra, Force constant, IR band assignments, Conformation.
 
Description FITR spectra and normal mode analysis of compound 2-[3-(p-flourobenzoyl)propyl]-1,2,3,4,6,7,12,12, a-octahydropyrazino[2′,1′:6,1] pyrido [3,4-b] indole [centbutindole], which is a potent nuroleptic drug and belong to a series of 2-substituted pyrazino-pyrido indoles. It also blind with 5HT2 receptors. It has shown good antihypotensive activity. The well known Wilsons G-F matrix method with Urey-Bradely force field has been used to evaluate the normal mode frequencies of vibration. Good agreement has been obtain between them and a set of 29 force field constants is established. The vibrational dynamics of the title compound is being reported using Urey Bradley force field. It has shown acute toxicity, gross behavior and central effects like anti convulsant activity, anti reserpine activity and stereo specificity of action. The conformation of the title compound was determined by X-ray diffraction. It is planned to determine the conformation in such cases by the application of Fourier Transform Infrared (FITR) spectroscopy and normal mode analysis. As a first step in this direction the FITR spectrum of the title compound has been recorded and its normal mode analysis is carried out. The assignments of the frequencies are based on the theoretically calculated frequencies have also been given their best assignment.
 
Publisher SMS Institute of Technology
 
Date 2015-06-11
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://www.myresearchjournals.com/index.php/SAMRIDDHI/article/view/1609
10.18090/samriddhi.v3i1.1609
 
Source SAMRIDDHI : A Journal of Physical Sciences, Engineering and Technology; Vol 3, No 1 (2012): SAMRIDDHI : A Journal of Physical Sciences, Engineering and Technology
2229-7111
 
Language eng
 
Relation https://www.myresearchjournals.com/index.php/SAMRIDDHI/article/view/1609/8844
 
Rights Copyright (c) SAMRIDDHI : A JOURNAL OF PHYSICAL SCIENCES, ENGINEERING AND TECHNOLOGY
 

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