Comparative Antidiabetic Study of three phytochemicals on STZ+HFD induced diabetic dyslipidemic rats

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Title Comparative Antidiabetic Study of three phytochemicals on STZ+HFD induced diabetic dyslipidemic rats
 
Creator Mishra, Chetna
Khalid, Monowar Alam
Tripathi, Dinesh
Mahdi, Abbas Ali
 
Description Objective: Phytochemicals which are derived from medicinal plants having properties to cure the early stage of diabetes and its complications according to various preliminary studies. Mangiferin, Camphene and Citral are a major chemical component of Mangifera indica (mango), Zingiber officinale (ginger) and  Cymbopogon citratus (lemongrass), respectively has been reported multiple biological activities like antioxidant, anti-inflammatory, antidiabetic antidyslipidemic, antimicrobial, antitumor etc. Aim of this study was to compare the anti-dyslipidemic, anti-diabetic as well as antioxidant effects of Mangiferin, Camphene and Citral on streptozotocin (STZ) + high-fat diet (HFD) induced diabetic dyslipidemic rats.
Material & Methods: Diabetes was induced by through an STZ at a dose of 35 mg/kg/b.w injected intraperitoneally (ip). Plasma insulin and Glycosylated Haemoglobin (HbA1c) were estimated by kits. Free Fatty Acids (FFA), Triglycerides (TG), Phospholipids, Small dense lipoproteins (s-LDL) and total cholesterol (TC) were also estimated in blood serum by using kits. Other biochemical parameters like Thiobarbituric acid reactive substances (TBARS), Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Reductase and reduced Glutathione (GSH) were estimated in the pancreas, skeletal muscles and adipose tissue homogenates spectrophotometrically.
Results: Citral has shown more degree of anti-hyperglycemic activity and antioxidant activity than mangiferin and camphene do. But, all three have produced a similar degree of hypolipidemic activity.
Conclusion: Current study shows that mangiferin, camphene and citral possess significant antidiabetic, antidyslipidemic and antioxidant properties thus it will provide new direction in the herbal treatment of diabetic dyslipidemia and related cardiovascular complications.
Keyword: Diabetes; Dyslipidemia; Mangiferin; Citral; Camphene; Oxidatives-Stress
 
Publisher Scholar Science Journals
 
Date 2018-08-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://ssjournals.com/index.php/ijbar/article/view/4862
10.7439/ijbar.v9i8.4862
 
Source International Journal of Biomedical and Advance Research; Vol 9 No 8 (2018): Aug; 286-293
2229-3809
2455-0558
 
Language eng
 
Relation http://ssjournals.com/index.php/ijbar/article/view/4862/3325
 
Rights Copyright (c) 2018 International Journal of Biomedical and Advance Research
https://creativecommons.org/licenses/by-nd/4.0
 

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