An update on the management of immune thrombocytopenic purpura and emerging treatment options: A review and case report

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Title An update on the management of immune thrombocytopenic purpura and emerging treatment options: A review and case report
 
Creator Krishnan, Rithu
Faisal K P, Mohammed
S, Merlin T
Oommen, Cijo
 
Description Immune thrombocytopenic purpura affects both children and adults. It is an autoimmune disorder characterised by persistent thrombocytopenia (peripheral platelet count of less than 150 x109/L) due to autoantibody binding to platelet antigen(s) causing their premature destruction by the reticulo-endothelial system, in particular the spleen. There is no gold standard diagnostic test to confirm ITP. The diagnosis of ITP remains clinical and is based principally on the exclusion of other causes of thrombocytopenia by the history, physical examination, full blood count, peripheral blood film and autoimmune screen. Medical options for front-line drug therapy are corticosteroids, intravenous immunoglobulin, and intravenous Rh anti-D. Second and third line therapy includes monoclonal antibodies and thrombopoirtin receptor agonist. Transfusion of platelet is warranted if life threatening hemorrhage occurs. This review gives a brief discussion on the pathophysiology, clinical presentation, diagnosis and treatment of Immune Thrombocutopenic Purpura and a case report.
 
Publisher Scholar Science Journals
 
Date 2016-07-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Research Article
 
Format application/pdf
 
Identifier http://ssjournals.com/index.php/ijpr/article/view/3416
10.7439/ijpr.v6i7.3416
 
Source International Journal of Pharmacological Research; Vol 6 No 7 (2016): Jul; 264-270
2277-3312
 
Language eng
 
Relation http://ssjournals.com/index.php/ijpr/article/view/3416/2437
 
Rights Copyright (c) 2016 International Journal of Pharmacological Research
http://creativecommons.org/licenses/by/4.0
 

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