Comparison of the Effects of Albumin 5% versus Ringer's Lactate on Blood Loss and Coagulation after Vascular Surgery Using Thromboelastography

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Title Comparison of the Effects of Albumin 5% versus Ringer's Lactate on Blood Loss and Coagulation after Vascular Surgery Using Thromboelastography
 
Creator Mohamed, Ahmed Abdalla
Elsharkawi, Nadia Gameel
Zaid, Osama Ismail
Mohamed, Ahmed Farag
Mohamed, Nashwa Nabeel
Wadeed, Michael Wahib
Tawfik, Adham Feteha
Elkatatny, Amr Abdelmonam Abdelaziz Mostafa
 
Subject Albumin 5%
Ringer's lactate
Vascular surgery
Blood loss
Coagulation
Thromboelastography
 
Description AIM: Comparing the effects of Albumin 5% versus Ringer's lactate on blood loss and coagulation after vascular surgery using
METHODS: In this randomised study, 60 patients, aged (18-60 years) ASA physical status (I-III) undergoing vascular surgery were included in the study and randomly allocated into two groups using a random number generator, to receive either Human albumin or Ringer lactate after obtaining written informed consent. Group A received 1-2 ml per minute of human albumin 5% combined with normal saline (0.9%). Group B received Ringer's lactate only as of the main solution. Variables were measured after administration of fluids as postoperative measures. The amount of blood needed for testing was 4 ml drawn before the operation and at the end of surgery with a citrate tube (blue tube) from the venous line or using a regular needle. The standard time of 15 minutes was considered to begin processing.
RESULTS: There was no statistically significant difference observed between both groups regarding demographic data, surgical wound drainage, haemoglobin level, hematocrit level and coagulation profile. Regarding ROTEM thermoelectrometry variables showed that there was no statistically significant difference was found between the two groups In-TEM variables (Ex-TEM Clotting time, TEM Clot Formation Time) but In-TEM Alpha Angel measured in degrees showed a Statistically significant difference between the two groups. P < 0.001 and Ex-TEM Maximum Clotting Firmness MCF values measured in mm, there was a statistically significant difference between the two groups P = 0.045.
CONCLUSION: This study concluded that the use of human albumin (5%) in vascular surgeries before reaching the trigger point for blood transfusion didn’t improve blood loss or coagulation profile compared to the use of ringer lactate only. Therefore, ringer lactate can be used as a good replacement for human albumin. Ringer lactate is readily available and inexpensive while human albumin may be costly.
 
Publisher Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia; ID Design 2012/DOOEL Skopje, Republic of Macedonia
 
Date 2019-05-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
application/pdf
 
Identifier https://www.id-press.eu/mjms/article/view/oamjms.2019.263
10.3889/oamjms.2019.263
 
Source Open Access Macedonian Journal of Medical Sciences; Vol 7 No 8 (2019): Apr 30 (OAMJMS); 1335-1341
1857-9655
 
Language eng
 
Relation https://www.id-press.eu/mjms/article/view/oamjms.2019.263/3280
https://www.id-press.eu/mjms/article/view/oamjms.2019.263/3260
 
Rights Copyright (c) 2019 Ahmed Abdalla Mohamed, Nadia Gameel Elsharkawi, Osama Ismail Zaid, Ahmed Farag Mohamed, Nashwa Nabeel Mohamed, Michael Wahib Wadeed, Adham Feteha Tawfik, Amr Abdelmonam Abdelaziz Mostafa Elkatatny
https://creativecommons.org/licenses/by-nc/4.0
 

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