Penambahan Ciprofloksacin Intravena terhadap Ceftriakson sebagai Terapi Antibiotik Empiris pada Pasien Pneumonia Rawat Inap: Perbandingan Biaya dan Efektivitas

Buletin Penelitian Kesehatan

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Title Penambahan Ciprofloksacin Intravena terhadap Ceftriakson sebagai Terapi Antibiotik Empiris pada Pasien Pneumonia Rawat Inap: Perbandingan Biaya dan Efektivitas
 
Creator Machlaurin, Afifah; University of Jember
Satibi, Satibi; University of Gadjah Mada
Yasin, Nanang Munif; University of Gadjah Mada
 
Subject pneumonia, ceftriaxone, ciprofloxacin, cost, effectiveness
 
Description AbstractIn clinical practices the aim of adding antibiotics treatment was to improve the outcomes. The objectiveof this study was to assess whether adding intravenous ciprofloxacin could bear more benefit despitethe cost of treatment than that of intravenous ceftriaxone for hospitalized pneumonia. This retrospectivestudy devided patients with pneumonia into two groups; first, patients received intravenous ceftriaxonetherapy only (CTX group), second, patients received combination of intravenous ceftriaxone plusciprofloxacin (CTXCP group). There were 171 patients recruited, 106 patients received CTX treatmentand 65 patients received CTXCP. The data were matched between groups by age, gender, level of paymentand comorbidities. The total cost of treating hospitalized pneumonia with CTXCP was higher than CTX(p=0,000). Meanwhile, the length of stay (LOS) and length of stay antbiotic related (LOSAR) were shorterin CTX group than CTXCP (11,32 vs 13,15 days, p=0,14 and 9,26 vs 12,09 days, p=0,000). Moreover, thesuccess rate and first line clinal failure avoided (CFA) in CTX group were better than CTXCP (81,13% vs66,15%, p=0,027 and 71,79% vs 44,62%, p=0,000). This research concluded that adding ciprofloxacinintravenous as empiric treatment of hospitalized pneumonia did not improve outcomes but significantlyincreased the cost of treatment.Keywords: pneumonia, ceftriaxone, ciprofloxacin, cost, effectiveness AbstrakSalah satu tujuan penambahan terapi antibiotik dalam praktek klinis adalah untuk meningkatkan hasilterapi. Namun hal tersebut dapat meningkatkan biaya perawatan. Tujuan dari penelitian ini adalahuntuk mengetahui apakah penambahan terapi antibiotik ciprofloksacin akan meningkatkan efektifitasmeskipun menambah biaya dibandingkan dengan monoterapi ceftriakson pada pasien pneumonia rawatinap. Penelitian ini mengambil data pasien pneumonia secara retrospektif dan membaginya menjadi duakelompok; pertama, kelompok monoterapi ceftriakson (CTX); kedua, kelompok kombinasi ciprofloksacindan ceftriakson (CTXCP). Sejumlah 171 pasien pneumonia yang memenuhi kriteria, 106 pasien masukkelompok CTX dan 65 pasien masuk dalam kelompok CTXCP. Kedua kelompok memiliki karakteristikyang sama dari segi jenis kelamin, usia, jenis pembayaran, dan penyakit komorbiditas. Hasil analisismenunjukkan total biaya perawatan pada kelompok CTXCP lebih tinggi dari pada kelompok CTX (Rp.12.120.000 vs Rp. 9.020.000, p=0,000). Perbandingan efektifitas menunjukkan lama rawat inap (lengthof stay,LOS) dan lama pemberian antibiotik saat rawat inap (length of stay antibiotic related,LOSAR)kelompok CTX lebih pendek dibandingkan CTXCP (11,32 vs 13,15 hari, p=0,14 and 9,26 vs 12,09hari, p=0,000). Selain itu, tingkat keberhasilan terapi dan kegagalan antibiotik pertama (first line clinicalfailure avoided,CFA) juga lebih bagus pada kelompok CTX (81,13% vs 66,15%, p=0,027 dan 71,79%vs 44,62%, p=0,000). Dari penelitian ini dapat disimpulkan bahwa penambahan terapi ciprofloksacin sebagai terapi empiris pada pasien pneumonia rawat inap membutuhkan biaya yang lebih tingginamun menghasilkan efektifitas yang lebih rendah dibandingkan monoterapi ceftriakson.Kata kunci: pneumonia, ceftriakson, ciprofloksacin, biaya, efektivitas
 
Publisher Badan Penelitian dan Pengembangan Kesehatan
 
Contributor
 
Date 2017-07-18
 
Type
 
Format application/pdf
 
Identifier http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/view/6392
10.22435/bpk.v45i2.6392.73-80
 
Source Buletin Penelitian Kesehatan; Vol 45, No 2 (2017); 73-80
Buletin Penelitian Kesehatan; Vol 45, No 2 (2017); 73-80
 
Language en
 
Relation http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6392/13867
http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6392/13868
http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6392/13869
http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6392/13870
http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6392/13871
 
Rights The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development) as publisher of the journal.Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development).Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal.
 

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