Uji Klinik Fase II Ramuan Jamu sebagai Pelindung Fungsi Hati

Buletin Penelitian Kesehatan

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Title Uji Klinik Fase II Ramuan Jamu sebagai Pelindung Fungsi Hati
 
Creator zulkarnain, zuraida -; Medicinal Plant and Traditional Medicine Research and Development Office National Institute of Health Research and Development, Ministry of Health Republic of Indonesia
Novianto, Fajar -; Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional
Saryanto, Saryanto -; Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional
 
Subject hepatoprotektor, Saintifikasi Jamu, curcuma, temulawak
 
Description AbstractThe human liver is susceptible to interference due to its complex function. The development ofhepatoprotective from jamu formula is still needed as to produce more effective, cheaper andsafer hepatoprotective. The result of previous study showed that the hepatoprotective from jamuformula was safe and efficacious. This phase 2 trial was conducted to evaluate the efficacy andsafety of hepatoprotective from jamu formula which consists of Curcuma longa rhizomes, Curcumaxanthorrhiza rhizomes, and Taraxacum officinale leaves. The design was open label randomizedclinical trial with silimarin as a comparison for 42 days intervention. Two hundreds of humansubjects participated in this study. The trial held in 2015 and involved 50 physician members ofSaintifikasi Jamu Network at several regencies in Indonesia. The parameters for assessing efficacywere SGPT, SGOT and as for safety were routine blood, urea, and creatinine. Clinical symptoms andpossible side effects were also observed. The results showed that the jamu formula can reduce theaverage value of SGPT and SGOT equal to silimarin. Jamu formula can relieve clinical symptomsarising from liver function disruption, and it is safe, it does not alter kidney function, hemoglobin,leukocyte count and platelet count in its use for 42 days.Keywords: hepatoprotective, Saintifikasi Jamu, Curcuma longa, Curcuma AbstrakHati mudah mengalami gangguan disebabkan fungsinya yang kompleks. Saat ini masih diperlukanpengembangan ramuan jamu untuk melindungi dan memperbaiki sel-sel hati (hepatoprotektor) yanglebih efektif, murah dan aman. Hasil penelitian observasi klinik terdahulu menunjukkan bahwaformula jamu untuk hepatoprotektor aman dan berkhasiat sehingga dilanjutkan dengan uji klinik fase2. Tujuan uji ini untuk menilai khasiat dan keamanan ramuan jamu sebagai hepatoprotektor dengankomposisi rimpang temulawak, rimpang kunyit, dan daun jombang. Rancangan uji adalah open labelrandomised clinical trial dengan pembanding silymarin dan lama perlakuan 42 hari. Jumlah sampel200 subjek manusia. Uji ini melibatkan 50 dokter jejaring saintifikasi jamu di beberapa wilayah diIndonesia pada tahun 2015. Parameter untuk menilai khasiat adalah SGPT, SGOT dan untuk menilaikeamanan adalah darah rutin, ureum, kreatinin. Gejala klinis dan kemungkinan efek samping jugadiamati. Hasil uji menunjukkan bahwa ramuan jamu uji mampu menurunkan rerata nilai SGPT danSGOT sebanding dengan silymarin. Ramuan jamu uji dapat meredakan gejala klinik yang timbulakibat gangguan fungsi hati, aman, tidak mengubah fungsi ginjal, hemoglobin, angka leukositmaupun angka trombosit pada penggunaan selama 42 hariKata kunci : hepatoprotektor, Saintifikasi Jamu, kunyit, temulawak, jombang
 
Publisher Badan Penelitian dan Pengembangan Kesehatan
 
Contributor Badan Litbangkes Kemenkes
 
Date 2017-07-18
 
Type
 
Format application/pdf
 
Identifier http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/view/6359
10.22435/bpk.v45i2.6359.125-136
 
Source Buletin Penelitian Kesehatan; Vol 45, No 2 (2017); 125-136
 
Language id
 
Relation http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6359/13729
http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6359/13730
http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/6359/13731
 
Rights The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development) as publisher of the journal.Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development).Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal.
 

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