Detection of Colistin Resistance in Uropathogenic Carbapenem Resistant Klebsiella pneumoniae
Asian Pacific Journal of Health Sciences
View Publication Info| Field | Value | |
| Title |
Detection of Colistin Resistance in Uropathogenic Carbapenem Resistant Klebsiella pneumoniae
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| Creator |
Ishrath Razia Riaz
Anusha Hindupur Thota Akhil Raj Iswarya Anbazhagan Prabu Dhandapani |
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| Subject |
Carbapenem resistance, Colistin resistance, Klebsiella pneumoniae, Urinary tract infection
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| Description |
Background: Colistin resistance among carbapenem-resistant Klebsiella pneumoniae (CRKp) strains at an accelerated rate poses a serious global threat which limits therapeutic options. Objective: In this study, 203 laboratory-archived uropathogenic K. pneumoniae isolates were screened for carbapenem and colistin resistance. Methods: Carbapenam resistance screening was performed using combined disc test. Colistin resistance was determined for CRKp isolates, according to clinical and laboratory standards institute- European Committee on Antimicrobial Susceptibility Testing guidelines. Polymerase Chain Reaction for carbapenamase genes (blaNDM-1, blaKPC-2 and blaOXA-1) and plasmid-mediated colistin resistance genes (mcr-1-2) were performed for the resistant isolates. Results: About 30% of the CRKp isolates were resistant to colistin; 57.1% and 35.7% of the isolates carried blaNDM-1 and blaOXA-1 gene, respectively. None of the isolates showed positive for blaKPC-2 and mcr (1-2) genes. Conclusion: Colistin resistance in the absence of a plasmid borne transfer mechanism was observed among our CRKp strains. Escalating colistin resistance is a crucial obstacle in treatment of K. pneumoniae infections and repurposing their usage is important to combat and control the resistance.
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| Publisher |
IJPMR Publishing Press
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| Date |
2022-01-15
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
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| Format |
application/pdf
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| Identifier |
https://www.apjhs.com/index.php/apjhs/article/view/1822
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| Source |
Asian Pacific Journal of Health Sciences; Vol. 9 No. 1 (2022): Vol 9 | Issue 1 | January - March 2022; 156-157
2349-0659 2350-0964 |
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| Language |
eng
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| Relation |
https://www.apjhs.com/index.php/apjhs/article/view/1822/1242
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| Rights |
Copyright (c) 2021 Ishrath Razia Riaz, Anusha Hindupur, Thota Akhil Raj, Iswarya Anbazhagan, Prabu Dhandapani
https://creativecommons.org/licenses/by/4.0 |
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