Detection of Colistin Resistance in Uropathogenic Carbapenem Resistant Klebsiella pneumoniae

Asian Pacific Journal of Health Sciences

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Field Value
 
Title Detection of Colistin Resistance in Uropathogenic Carbapenem Resistant Klebsiella pneumoniae
 
Creator Ishrath Razia Riaz
Anusha Hindupur
Thota Akhil Raj
Iswarya Anbazhagan
Prabu Dhandapani
 
Subject Carbapenem resistance, Colistin resistance, Klebsiella pneumoniae, Urinary tract infection
 
Description Background: Colistin resistance among carbapenem-resistant Klebsiella pneumoniae (CRKp) strains at an accelerated rate poses a serious global threat which limits therapeutic options. Objective: In this study, 203 laboratory-archived uropathogenic K. pneumoniae isolates were screened for carbapenem and colistin resistance. Methods: Carbapenam resistance screening was performed using combined disc test. Colistin resistance was determined for CRKp isolates, according to clinical and laboratory standards institute- European Committee on Antimicrobial Susceptibility Testing guidelines. Polymerase Chain Reaction for carbapenamase genes (blaNDM-1, blaKPC-2 and blaOXA-1) and plasmid-mediated colistin resistance genes (mcr-1-2) were performed for the resistant isolates. Results: About 30% of the CRKp isolates were resistant to colistin; 57.1% and 35.7% of the isolates carried blaNDM-1 and blaOXA-1 gene, respectively. None of the isolates showed positive for blaKPC-2 and mcr (1-2) genes. Conclusion: Colistin resistance in the absence of a plasmid borne transfer mechanism was observed among our CRKp strains. Escalating colistin resistance is a crucial obstacle in treatment of K. pneumoniae infections and repurposing their usage is important to combat and control the resistance.
 
Publisher IJPMR Publishing Press
 
Date 2022-01-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://www.apjhs.com/index.php/apjhs/article/view/1822
 
Source Asian Pacific Journal of Health Sciences; Vol. 9 No. 1 (2022): Vol 9 | Issue 1 | January - March 2022; 156-157
2349-0659
2350-0964
 
Language eng
 
Relation https://www.apjhs.com/index.php/apjhs/article/view/1822/1242
 
Rights Copyright (c) 2021 Ishrath Razia Riaz, Anusha Hindupur, Thota Akhil Raj, Iswarya Anbazhagan, Prabu Dhandapani
https://creativecommons.org/licenses/by/4.0
 

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