Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract

Tropical Animal Science Journal

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Field Value
 
Title Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract
 
Creator Yusfiati
Manalu, W.
Maheshwari, H.
Andryanto
 
Subject superoxide dismutase
repairing activity
uterus
tristaniopsis
 
Description The study examined the effectiveness of ethyl-acetate fraction of Pelawan extract on the activities of superoxide dismutases in physiological repairing of uterus in postpartum rat based on SOD activity, MDA concentration, and Cu, Zn SOD expressions. The experiment was arranged with a factorial, completely randomized design. Seventy-two female rats were divided into 4 groups, namely, control 1 (P01= 9), control 2 (P02= 9), giving birth once (P1= 27), and giving birth twice (P2= 27). The experimental rats were given treatments orally with 4 doses, namely 0 mg/kg BW, 50 mg/kg BW, 100 mg/kg BW, and 150 mg/kg BW. Observation data were taken on days 0, 3, and 5 after parturition. Variables measured were SOD activity, MDA levels, and the number of cells in the uterine tissue expressing Cu, Zn SOD. The results of studies on the condition of P01, P02, P1, and P2 showed significant changes in Cu, Zn SOD expressions. The low of SOD and MDA activities were found at doses of 100 mg and 150 mg. The high number of cells expressing Cu, Zn SOD in the epithelium cells and gland cells were found at a dose of 100 mg. Antioxidant plant extracts and their dosages determine the activities of SOD, MDA, and Cu, Zn SOD expressions in the uterus that will affect the process of repairing and involution of uterine tissue. Allegedly, the bioactive compounds extracted at certain doses effectively affect the physiological repair of cells in the uterine tissue of postpartum mothers.
 
Publisher Faculty of Animal Science, Bogor Agricultural University
 
Date 2021-11-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://journal.ipb.ac.id/index.php/tasj/article/view/33026
10.5398/tasj.2021.44.4.415
 
Source Tropical Animal Science Journal; Vol. 44 No. 4 (2021): Tropical Animal Science Journal; 415-424
2615-790X
2615-787X
10.5398/tasj.2021.44.4
 
Language eng
 
Relation http://journal.ipb.ac.id/index.php/tasj/article/view/33026/22487
 
Rights Copyright (c) 2021 Tropical Animal Science Journal
http://creativecommons.org/licenses/by-sa/4.0
 

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