Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities

ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY

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Field Value
 
Title Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities
 
Creator Uthirapathy, Subasini
Tahir, Tara F.
 
Subject Antioxidants
Cardiac markers
Gas chromatography–mass spectrometer
Isoproterenol
Lipid
Triton WR 1339
 
Description Withania somnifera (WS) (Dunal) or Ashwagandha is a well-known hypolipidemic herb and antioxidant. In this study, 75% ethanolic extract of WS is attempted to evaluate the cardioprotective activity of isoproterenol-induced cardiotoxicity and hypolipidemic activity in Triton WR 1339-induced hyperlipidemia. In addition, phytochemical evaluation of the same extracts analyzed by gas chromatography–mass spectrometer (GC–MS). This study found that 7 days of therapy with WS extracts at 1000 mg/kg b.wt. reduced cholesterol by 76%, low-density lipoprotein (LDL) by 71%, and TAG by 12% (P < 0.05). Furthermore, it can significantly reduce cholesterol and LDL levels (P < 0.05). Similarly, the use of 50 mg/kg b.wt. of WS extract showed a cardioprotective effect against isoproterenol-induced cardiac toxic rats. The antioxidants glutathione, glutathione peroxidase, and catalase are increased in WS extract (P < 0.05), whereas the release of cardiac indicators in heart tissue is reduced (P < 0.05). Furthermore, a 30-day treatment with WS also reduced triacylglycerol in isoprenaline-induced cardiotoxic rats. GC–MS analysis of the methanol fraction of the Ashwagandha 70% ethanolic extract showed the presence of higher concentrations of fatty acids. In conclusion, WS showed hypolipidemic and cardioprotective activities in diseased animals induced by isoproterenol and Triton WR 1339.
 
Publisher Koya University
 
Date 2021-10-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed article
text
 
Format application/pdf
 
Identifier http://aro.koyauniversity.org/index.php/aro/article/view/844
10.14500/aro.10844
 
Source ARO-THE SCIENTIFIC JOURNAL OF KOYA UNIVERSITY; Vol. 9 No. 2 (2021): Issue Seventeen; 15-21
2307-549X
2410-9355
 
Language eng
 
Relation http://aro.koyauniversity.org/index.php/aro/article/view/844/220
 
Rights Copyright (c) 2021 Subasini Uthirapathy, Tara F. Tahir
https://creativecommons.org/licenses/by-nc-sa/4.0
 

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