PERIPHERAL PARASITAEMIA AND ITS ASSOCIATION WITH PLASMA CYTOKINES LEVELS IN MALARIA-INFECTED PREGNANT WOMEN IN ABA, ABIA STATE, NIGERIA

African Journal of Infectious Diseases (AJID)

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Title PERIPHERAL PARASITAEMIA AND ITS ASSOCIATION WITH PLASMA CYTOKINES LEVELS IN MALARIA-INFECTED PREGNANT WOMEN IN ABA, ABIA STATE, NIGERIA
 
Creator Ifeanyichukwu, M.O.
Okamgba, O.C.
Amilo, G.I.
Nwokorie, E.A.
 
Subject Tradtional Medicine, Medicinal Plants
Malaria, pregnancy, cytokines, woman, association
 
Description Background: Cytokines in pregnant female may not be a normal phenomenon as malarial infection is often associated with strong
CD4+ cell activation and up-regulation of pro-inflammatory cytokines. We investigated the relationship between peripheral
parasitaemia and plasma levels of cytokines among malaria infected pregnant women in Aba, Abia State, Nigeria.
Materials and Methods: A total of 206 non-HIV positive asymptomatic malaria parasitaemic (n=144) and non-parasitaemic
(n=62) pregnant women were recruited for this study alongside 80 non-pregnant women who served as positive (n=40) and
negative (n=40) controls. Blood samples were aseptically collected from each subject and tested for HIV and malaria parasites
using standard methods. Also, plasma levels of cytokines were measured using Th1/Th2 human cytokine ELISA kits (Abcam,
UK). Analysis of Variance and Student’s t-test were used for Comparison of groups while Pearson’s Correlation Coefficient was
used for tests of association.
Results: The results revealed a mean parasite density of 685.56±484.55 parasites/μl of blood. Malaria infected pregnant subjects
showed significantly higher levels of IFN-γ, TNF-α, IL-4, IL-6 and IL-10 when compared with their non-infected counterparts
(P< 0.05). The cytokines evaluated were higher in moderate parasitaemia than mild parasitaemia. Positive correlation existed
between peripheral parasite density (PPD) and IL-4 (r= 0.24, P=0.004), PPD and IL-6 (r = 0.35, P = 0.001) as well as PPD and IL-
10 (r = 0.29, P = 0.001).
Conclusion: This study showed that increase in peripheral parasitaemia increased levels of some plasma cytokines (IL-4, IL-6 and
IL-10) but not IFN-γ and TNF-α in the malaria infected pregnant women studied.
 
Publisher African Traditional Medicine Supporters Initiative (ATHMSI), 7, Road 1, Otunmaiye Square
 
Contributor The pregnant women at the antenatal clinics and the immediate post-partum women who voluntarily participated in this study. Dr Nkiru Nwagbo, Clara Igwe and J.I. Iruka are acknowledged for their assistance in collecting specimens. Measurements of parasitol
 
Date 2017-06-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://journals.sfu.ca/africanem/index.php/AJID/article/view/4791
10.21010/ajid.v11i2.7
 
Source African Journal of Infectious Diseases (AJID); Vol 11, No 2 (2017); 54-61
2505-0419
2006-0165
 
Language eng
 
Relation http://journals.sfu.ca/africanem/index.php/AJID/article/view/4791/2994
 
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Rights Copyright (c) 2017 African Journal of Infectious Diseases (AJID)
 

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