Synthesis, characterization and antimicrobial evaluations of mixed ligand complexes of sulphamethaxole and metronidaxole with some transistion metals (Zn, Co, Cu and Fe) in water methanol medium

International Journal for Innovation Education and Research

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Title Synthesis, characterization and antimicrobial evaluations of mixed ligand complexes of sulphamethaxole and metronidaxole with some transistion metals (Zn, Co, Cu and Fe) in water methanol medium
 
Creator Olagboye, Suleiman A.
Bamisaye, Blessing John
Adesugba, Jerome Femi
 
Subject Sulfamethoxazole
Metronidazole
Antimicrobial
Metal complexes and Spectroscopic study
 
Description Sulfamethoxazole and metronidazole are antibiotics use for the treatment of various bacterial infections. Their use as ligand is very prominent in formation of metal complexes. The transition metal complexes are synthesized by reaction of Sulfamethoxazole and metronidazole with metals such Mn(II), Cu(II), Fe(II) and Ni(II). The synthesized metal complexes are tested as antibacterial and antifungal. The antimicrobial activity of the complexes displays good potency against some microorganism such as Xanthomonas axonopodis, Streptococcus faecalia, Salmonella entrica, Claribacter michiganense, Xanthomonas phaseolin for bacteria and S.roofisii, M.phonoides, C.lindimuthianum for the fungi, it is revealed that all copper complexes show stronger antibacterial activity than the free drugs. The spectroscopic properties of the complexes were investigated using UV/visible and FT-IR which show metal-charge from 3d to 3s transition in which the transition state shows that they are octahedral geometry and their coordination site respectively. Their percentage yield was moderately high and producible. The complexes synthesized have higher inhibitory activities than the free ligand. The drug resistance in microbes is resulting in the incompetence of available drugs to care for the infections. The thermal analysis shows that the complexes are stable.
 
Publisher International Educative Research Foundation Publisher (IERFP)
 
Date 2021-08-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://ijier.net/index.php/ijier/article/view/3067
10.31686/ijier.vol9.iss8.3067
 
Source International Journal for Innovation Education and Research; Vol. 9 No. 8 (2021): International Journal for Innovation Education and Research; 13-23
2411-2933
2411-3123
 
Language eng
 
Relation https://ijier.net/index.php/ijier/article/view/3067/2231
 
Rights Copyright (c) 2021 Suleiman A. Olagboye, Blessing John Bamisaye, Jerome Femi Adesugba
https://creativecommons.org/licenses/by-nd/4.0
 

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