A Comparative Study of Clonidine versus Dexmedetomidine as an Adjunct to Hyperbaric Bupivacaine in Spinal Anesthesia for Orthopaedic Lower Limb Surgeries

Academia Anesthesiologica International

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Title A Comparative Study of Clonidine versus Dexmedetomidine as an Adjunct to Hyperbaric Bupivacaine in Spinal Anesthesia for Orthopaedic Lower Limb Surgeries
 
Creator Shruti Hiremath
S. Ashwini
 
Subject Bupivacaine
Clonidine
Dexmedetomidine
Motor Block
 
Description Background: To compare clonidine versus dexmedetomidine as an adjunct to hyperbaric bupivacaine in spinal anesthesia in lower limb surg- eries. Subjects & Methods: Ninety patients belonging to physical status American Society of Anesthesiologists (ASA) Classes I and II between 18- 60 years’ age group posted for limb surgeries of both genders were randomly divided into 2 groups. Group I were given 3.5 ml volume of injection bupivacaine 0.5% hyperbaric and 0.5 ml normal saline. Group II patients were given 3.5 ml volume of injection bupivacaine 0.5% hyperbaric and 0.5 ml of injection clonidine (30 µg) and group III patients were prescribed 3.5 ml volume of injection bupivacaine 0.5% hyperbaric and 0.5 ml of injection dexmedetomidine (5 µg). Parameters such as sensory onset, motor onset, duration of motor blockade, time for rescue analgesia, VAS and adverse effects were recorded in both groups. Results: Common adverse events such as nausea in 3 in group I,  1 in group 1 and 2 in group II, bradycardia 2 in group I, 1 in both group II and III, hypotension 2 in group I and group II and 1 in group III and shivering 1 in group I. Sensory onset duration was 2.9 minutes in group I, 1.5 minutes in group II and 1.3 minutes in group III, motor onset duration was 4.1 minutes in group I, 1.7 minutes in group II and 1.2 minutes in group III, duration of motor blockade was 168.2 minutes in group I, 281.4 minutes in group II and 304.2 minutes in group III, time for rescue analgesia was 168.5 minutes in group I, 345.7 minutes in group II and 367.2 minutes in group III and VAS was 6.0 minutes in group I, 5.0 minutes in group II and 4.8 minutes in group III. A significant difference was found in all parameters (P< 0.05). Conclusion: α2-agonists with hyperbaric bupivacaine intrathecally have a faster onset of both motor and sensory block, prolonged duration of block and better post operative analgesia
 
Publisher Society for Health Care & Research Development
 
Date 2021-06-20
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
application/xml
text/html
application/epub+zip
 
Identifier https://aijournals.com/index.php/aan/article/view/1996
 
Source Academia Anesthesiologica International; Vol 6 No 1 (2021): January-June 2021; 137- 141
2456-7388
2617-5479
 
Language eng
 
Relation https://aijournals.com/index.php/aan/article/view/1996/2448
https://aijournals.com/index.php/aan/article/view/1996/2449
https://aijournals.com/index.php/aan/article/view/1996/2450
https://aijournals.com/index.php/aan/article/view/1996/2451
 
Rights Copyright (c) 2021 Author
https://creativecommons.org/licenses/by/4.0/
 

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