Prospective Randomized Double Blind Study to Evaluate the Analgesic Efficacy of Low Dose of Intrathecal Neostigmine in Combination with Fentanyl and Bupivacaine for Lower Abdominal and Lower Limb Surgery

Academia Anesthesiologica International

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Title Prospective Randomized Double Blind Study to Evaluate the Analgesic Efficacy of Low Dose of Intrathecal Neostigmine in Combination with Fentanyl and Bupivacaine for Lower Abdominal and Lower Limb Surgery
 
Creator Prakash, Bhanu
Kumar, Arti Raj
Valsamma Abraham
 
Subject Spinal Anesthesia
Intrathecal
Fentanyl
Neostigmine
 
Description Background: More than 80% of patients undergoing surgical procedures under spinal anesthesia experience acute post-operative pain. The present study was conducted with aim to compare the analgesic efficacy and side effects of addition of neostigmine to fentanyl and bupivacaine. Subjects and Methodology: The study was conducted at Christian Medical College and Hospital, Ludhiana in the Department of Anaesthesia and Critical Care, from 15th Oct 2015 to 14th Oct 2016. 50 patients aged between 18 - 60 years belonging to the ASA grade I & II undergoing elective surgery for lower abdominal and limb region (likely to finish within 3 hours), were divided into 2 groups(25 each) . Group A was given Intrathecal Bupivacaine 12.5 mg (2.5 ml) + Fentanyl 20 µg (0.4 ml)+0.1 ml Normal Saline (Total 3 ml) and Group B was given Intrathecal Bupivacaine 12.5 mg (2.5 ml) + Fentanyl 20 µg (0.4 ml) + Neostigmine 1µg (0.1 ml) (Total 3 ml). Various parameters such as sensory and motor block onset, point of maximum sensory level attainment, VAS pain score, rescue analgesia and adverse effects were recorded. Results: The results showed that both the groups showed statistically significant difference in terms of sensory blockade and recovery of sensory blockade was. It was observed that group B showed the early onset of sensory blockade and prlonged recovery time. No difference was seen in maximal sensory blockade. Conclusion: Intrathecal neostigmine precipitated the onset of motor and sensory blockade and prolongs the block significantly when used with bupivacaine and fentanyl in spinal anesthesia in a low dose. The duration of analgesia was also significantly prolonged when neostigmine is added. Although the addition of neostigmine produced side effects like nausea and hypo tension, they were not statistically significant and were cautiously managed.
 
Publisher Society for Health Care & Research Development
 
Date 2021-06-17
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
application/xml
text/html
application/epub+zip
 
Identifier https://aijournals.com/index.php/aan/article/view/1966
 
Source Academia Anesthesiologica International; Vol 6 No 1 (2021): January-June 2021; 125-130
2456-7388
2617-5479
 
Language eng
 
Relation https://aijournals.com/index.php/aan/article/view/1966/2336
https://aijournals.com/index.php/aan/article/view/1966/2337
https://aijournals.com/index.php/aan/article/view/1966/2338
https://aijournals.com/index.php/aan/article/view/1966/2339
 
Rights Copyright (c) 2021 Author
https://creativecommons.org/licenses/by/4.0/
 

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