Changes in Bovine Colostrum Metabolites during Early Postpartum Period Revealed by 1H-NMR Metabolomics Approach

Tropical Animal Science Journal

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Field Value
 
Title Changes in Bovine Colostrum Metabolites during Early Postpartum Period Revealed by 1H-NMR Metabolomics Approach
 
Creator Settachaimongkon, S.
Wannakajeepiboon, N.
Arunpunporn, P.
Mekboonsonglarp, W.
Makarapong, D.
 
Subject dairy
milk
colostrum
metabolomics
foodomics
 
Description The objectives of this study were to characterize and compare non-volatile polar metabolite profiles of bovine colostrum, collected within 1 h and at 72 h after parturition, from crossbred Holstein cows raised in northeastern Thailand. The colostrum serum was characterized and compared using a non-targeted proton nuclear magnetic resonance (1H-NMR) technique combined with chemometric analysis. Results demonstrated that the main effect of post-parturition time provided a significant impact on the physical properties and major chemical constituents of colostrum, while the influence of farm origin and sampling month were likely undetectable. The 1H-NMR technique enabled to identify 45 non-volatile polar metabolites in the samples. Partial least-squares-discriminant analysis (PLS-DA) allowed discrimination of colostrum metabolome not only according to different times after parturition, but also the origins of the farm as well as sampling months. Differential metabolites were statistically identified as potential biomarkers accountable for the discrimination. Besides basic nutritive compounds (amino acids and sugars), several bioactive metabolites such as ascorbate, creatine, carnitine, choline, acetylcarnitine, N-acetylglucosamine, ornithine, orotate, and UPD-glucose could be successfully elucidated. Our finding reveals the application of non-targeted 1H-NMR metabolomics as an effective tool to assess the biomolecular profiles of bovine colostrum and their essential dynamics during the first three days after parturition.
 
Publisher Faculty of Animal Science, Bogor Agricultural University
 
Date 2021-06-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://journal.ipb.ac.id/index.php/tasj/article/view/32598
10.5398/tasj.2021.44.2.229
 
Source Tropical Animal Science Journal; Vol. 44 No. 2 (2021): Tropical Animal Science Journal; 229-239
2615-790X
2615-787X
10.5398/tasj.2021.44.2
 
Language eng
 
Relation http://journal.ipb.ac.id/index.php/tasj/article/view/32598/21705
 
Rights Copyright (c) 2021 Tropical Animal Science Journal
http://creativecommons.org/licenses/by-sa/4.0
 

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