Jurnal Ilmiah Manuntung

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Field Value
 
Title
PENGARUH TRIGLISERIDA TERHADAP KADAR LEPTIN PADA USIA LANJUT DENGAN GANGGUAN KOGNITIF



 
Creator Syafrita, Yuliarni
Eryanti, Lusi
 
Description There are some relationships between cognitive impairment with elevation of triglycerides and reduction of leptin concentration in elderly. The elevation of serum triglycerides concentration leads to leptin resistance resulting in impairment of leptin ability to cross blood brain barrier and decrease leptin concentration in brain. The aim of this study is to determine the correlation between triglycerides serum concentration towards leptin concentration in elderly with cognitive impairment.  This was a cross sectional study conducted at Neurology Clinic Dr. M. Djamil Hospital. Cognitive function was assessed by using MoCA-Ina, concentration of triglycerides was measured by using enzymatic GPO-PAP method and concentration of leptin was measured by using ELISA. The correlation between two variables was analyzed by using Mann-Whitney test and correlation between triglycerides concentration with leptin was analyzed by using Spearman test. The p value ≤ 0.05 was statistically significant. There are mean triglycerides differences between elderly groups with cognitive impairment (160 (54 – 397)) and elderly groups with normal cognitive function (107 (53 – 249)) with p= 0.005. There are no leptin concentration differences between elderly with cognitive impairment (8,6 (0,96-36,92)) and elderly with normal cognitive function (11,73 (0,71 -36,66 )) with p= 0.45. There are negative correlations between triglycerides concentration with leptin concentration in groups with cognitive impairment, but the correlation is weak (r=0,347, p=0,134). There is negative correlation between triglycerides concentration with cognitive function. There is no correlation between leptin concentration in elderly with cognitive impairment.
 
Publisher jurnal ilmiah manuntung akademi farmasi samarinda
 
Date 2021-05-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://jurnal.akfarsam.ac.id/index.php/jim_akfarsam/article/view/425
10.51352/jim.v7i1.425
 
Source Jurnal Ilmiah Manuntung; Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung; 79-85
Jurnal Ilmiah Manuntung; Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung; 79-85
2477-1821
2443-115X
10.51352/jim.v7i1
 
Language eng
 
Relation http://jurnal.akfarsam.ac.id/index.php/jim_akfarsam/article/view/425/208
 
Rights Copyright (c) 2021 Jurnal Ilmiah Manuntung
http://creativecommons.org/licenses/by-sa/4.0
 

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