Evaluation of antimicrobial and antibiofilm activities of stingless bee Trigona honey (Malaysia) against Streptococcus pneumoniae

The International Arabic Journal of Antimicrobial Agents

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Field Value
 
Title Evaluation of antimicrobial and antibiofilm activities of stingless bee Trigona honey (Malaysia) against Streptococcus pneumoniae
 
Creator Alkafaween, Mohammad A.
Al-Jamal, Hamid A. Nagi
Mohmd Hilmi, Abu Bakar
 
Description Background: The study aims to evaluate the antibacterial activity of Trigona honey against S. pneumonia. Methods: The effect of Trigona honey on S. pneumonia investigated using agar well diffusion, MIC, MBC, biofilm formation and RT-qPCR.
Results: Trigona honey samples showed the larger zones of inhibition against S. pneumonia, 22.2±0.4 at 100% concentration. Trigona honey possessed the lowest MIC, MBC, MIC50 and MIC90 against S. pneumoniae, 25%, 30%, 12.5% and 25% (w/v) respectively. Trigona honey permeated established biofilms of S. pneumonia, resulting in significant decreased the cells from the biofilm. RT-qPCR revealed that the expression of genes amiF, ftsY, mvaS, pnpA, argG, mvd1, purN, miaA and pbp2a were upregulated, glcK, marR, prmA and ccpA­­­ were downregulated after exposure to honey.
Conclusion: Trigona honey demonstrated the highest antibacterial activity against S. pneumoniae. By limiting study in vitro on Trigona honey, we infer that Trigona honey impacts on S. pneumoniae.
 
Publisher International Medical Publisher
 
Date 2021-05-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://imed.pub/ojs/index.php/IAJAA/article/view/2382
10.3823/856
 
Source The International Arabic Journal of Antimicrobial Agents; Vol 11 No 2 (2021)
2174-9094
 
Language eng
 
Relation http://imed.pub/ojs/index.php/IAJAA/article/view/2382/2114
 
Rights Copyright (c) 2021 Mohammad A. Alkafaween, Hamid A. Nagi Al-Jamal, Abu Bakar Mohmd Hilmi
http://creativecommons.org/licenses/by/4.0
 

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