Efektivitas gel ekstrak etanol daun senggani (Melastoma candidum D. Don.) terhadap diameter luka pasca pencabutan gigi pada tikus putih (Rattus norvegicus)

Bioma jurnal ilmiah biologi

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Title Efektivitas gel ekstrak etanol daun senggani (Melastoma candidum D. Don.) terhadap diameter luka pasca pencabutan gigi pada tikus putih (Rattus norvegicus)
 
Creator Halim, Susanna
Halim, Hariyanto
Lister, I Nyoman Ehrich
Sihotang, Saipul
Nasution, Ali Napiah
Girsang, Ermi
 
Description ABSTRAKDaun senggani (Melastoma candidum D. Don.) mengandung flavonoid, triterpenoid, tanin, saponin, steroid, glikosida, dan fenolik yang berfungsi sebagai antioksidan, antiinflamasi, dan bersifat antifungi, antivirus dan antibakteri. Penelitian ini bertujuan untuk mengetahui konsentrasi ekstrak daun senggani (M. candidum D. Don.) yang memberikan efektivitas terbaik terhadap penyembuhan luka pasca pencabutan gigi pada tikus putih (Rattus norvegicus). Hasil ekstraksi daun senggani diformulasikan dalam bentuk salep dengan konsentrasi 1%, 3%, 5%, dan 10%. Hasil data rata-rata persentase kesembuhan luka yang terlihat dari diameter luka diuji secara statistik menggunakan SPSS versi 23. Hasil analisis pada hari ke-5 menunjukkan salep ekstrak etanol daun senggani (M. candidum D. Don.) konsentrasi 10% memiliki efektivitas penyembuhan luka yaitu sekitar 2,96 mm (p>0,05). Hasil skrining fitokimia daun senggani menunjukkan adanya senyawa metabolit sekunder seperti tanin, saponin, flavonoid, streroid/triterpene, dan glikosida. Kata kunci: ekstrak; gel; luka gigi; Melastoma candidum D. Don.  ABSTRACTThe effectiveness of senggani (Melastoma candidum D. Don.) leaves ethanolic gel extract on wound diameter after tooth extraction in Rattus norvegicus.Senggani (Melastoma candidum D. Don.) contains flavonoid, triterpenoid, tanin, saponin, steroid, glicoside, and phenolic compound which use as antioxidant, antiinflamation, antifungus, antivirus, and antibacteria. This study aims to determine the concentration of senggani (M. candidum D. Don.) leaves extract which gives the best effectiveness on wound healing after tooth extraction in Rattus norvegicus. The results of senggani (M. candidum D. Don.) leaves extraction was formulated in the form of ointments with concentrations of 1%, 3%, 5%, and 10%. The results of the average data on the percentage of wound healing visible from the diameter of the wound were statistically tested using SPSS version 23. The results of the analysis on the day 5 showed the ointment of 10% ethanolic extract of senggani (M. candidum D. Don.) leaves  had an effective wound healing of about 2.96 mm (p> 0.05). Furthermore, the results of phytochemical screening are secondary metabolites such as tanins, saponins, flavonoids, streroids/triterpene and glycosides. Keywords: extract; gel; tooth wounds; Melastoma candidum D. Don.
 
Publisher Universitas PGRI Semarang
 
Contributor
 
Date 2021-03-09
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://journal.upgris.ac.id/index.php/bioma/article/view/6555
10.26877/bioma.v10i1.6555
 
Source Bioma : Jurnal Ilmiah Biologi; Vol. 10 No. 1: April 2021; 44-54
2549-9890
2086-5481
 
Language eng
 
Relation http://journal.upgris.ac.id/index.php/bioma/article/view/6555/3945
 
Rights Copyright (c) 2021 Bioma : Jurnal Ilmiah Biologi
 

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