Interactome analysis and docking sites prediction of (AtCHR8, AtCUL4 and AtERCC1/UVR7) proteins in Arabidopsis Thaliana

Heritage and Sustainable Development

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Title Interactome analysis and docking sites prediction of (AtCHR8, AtCUL4 and AtERCC1/UVR7) proteins in Arabidopsis Thaliana
 
Creator Abdel Gawwad, Mohamed Ragab
Ozdemir, Ali Taha
 
Description The UV irradiation is a major DNA damaging factor in plants. Arabidopsis thaliana uses various repair pathways for these kinds of DNA lesions. One of them is the nucleotide excision repair pathway. The AtCUL4, ERCC1/UVR7 and CHR8 are vital proteins for nucleotide excision pathway and mutations in these proteins cause flaws in the repair mechanism. Two of these proteins play crucial role during DNA damage recognition and the other is involved in the excision of damaged bases. During NER processes, Arabidopsis uses different sets of proteins during the DNA damage recognition for transcriptionally active and genomic DNA. In order to get better insight into these proteins, we used bioinformatics tools to predict, analyze, and validate 3D structures of ERCC1/UVR7, AtCUL4 and CHR8. We also predicted the subcellular and sub-nuclear localization of proteins. Subsequently, we predicted the docking sites for each individual proteins and searched for interacting residues which mediate the protein-protein interactions. 
 
Publisher Research and Development Academy - ARDA
 
Date 2020-06-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://hsd.ardascience.com/index.php/journal/article/view/32
10.37868/hsd.v2i1.32
 
Source Heritage and Sustainable Development; Vol. 2 No. 1 (2020); 52-68
2712-0554
10.37868/hsd.v2i1
 
Language eng
 
Relation https://hsd.ardascience.com/index.php/journal/article/view/32/26
 
Rights Copyright (c) 2020 Mohamed Ragab Abdel Gawwad, Ali Taha Ozdemir
https://creativecommons.org/licenses/by/4.0
 

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