Orthobiologic treatment with platelet-rich plasma. Systematic review and classification of evidence

Medicina y Laboratorio

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Title Orthobiologic treatment with platelet-rich plasma. Systematic review and classification of evidence
Tratamiento ortobiológico con plasma rico en plaquetas. Revisión sistemática y clasificación de la evidencia
 
Creator Vizcaíno-Salazar, Gilberto J.
 
Subject platelet-rich plasma
osteoarthritis
musculoskeletal diseasess
maxillo-facial surgery
plastic surgery
dermatology.
plasma rico en plaquetas
osteoartritis
enfermedades musculoesqueléticas
cirugía maxilofacial
cirugía plástica
dermatología.
 
Description  
 
Introduction. The use of platelet-rich plasma (PRP), autologous plasma with a number of platelets higher than that of basal plasma, after having been subjected to some extraction and concentration process, has taken a noticeable rise to stimulate tissue regeneration in musculoskeletal and soft tissue disorders. The objective of this study is to systematically review the efficacy of treatment with PRP in some musculoskeletal and soft tissue injuries, in plastic and maxillofacial surgery, as well as in dentistry and dermatology, with their level of evidence and grade of recommendation. Methodology. The search was performed using MeSH terms in PubMed, Google Scholar and the Cochrane Library. A total of 44 articles that met the inclusion and exclusion criteria were analyzed. Results. Analysis of the studies found that the level of evidence was level 1 in 75%, level 2 in 15.9%, level 3 in 6.8%, and level 4 in 2.2%. The grade of recommendations was distributed between good and favorable; 40.9% reflected grade A, 50% grade B, and 9% grade C. However, 50% of the studies reported in their conclusions that there is a deficiency in the methodology, with inconsistency in their results. Conclusion. These findings indicate that the evidence found shows contradictory results, most of them do not show a firm proof that supports their routine use, because their designs and statistical power are of low quality. It is necessary to unify criteria and research designs with highly recommended scientific evidence so that the use of PRP as an orthobiological agent in these pathologies could be widely accepted.
 
 
Introducción. El empleo del plasma rico en plaquetas (PRP) o plasma autólogo con una cifra de plaquetas superior a la del plasma basal, ha tomado un auge notorio para estimular la regeneración tisular en las afecciones musculoesqueléticas y de tejidos blandos. El objetivo de este estudio fue revisar sistemáticamente la eficacia del tratamiento con PRP en algunas lesiones musculoesqueléticas y de tejidos blandos en cirugía plástica y maxilofacial, así como en odontología y dermatología, con su nivel de evidencia y grado de recomendación. Metodología. Se utilizaron los buscadores PubMed, Google Académico y la Biblioteca Cochrane con terminología MeSH. Se analizaron un total de 44 artículos que cumplieron los criterios de inclusión y exclusión. Resultados. El análisis de los estudios encontró que el nivel de evidencia fue de 1 en el 75%, nivel 2 en el 15,9%, nivel 3 en el 6,8%, y nivel 4 en el 2,2%. El grado de recomendación se distribuyó entre bueno y favorable; el 40,9% de los estudios reflejaron grado A, 50% grado B y 9% grado C. No obstante, el 50% de los estudios reportaron en sus conclusiones que hay una deficiencia en el diseño metodológico, con inconsistencia en sus resultados. Conclusión. Estos hallazgos señalan que en la evidencia encontrada se observan resultados contradictorios, la mayoría de ellos no muestran una prueba firme que apoye el empleo rutinario del PRP, porque sus diseños y poder estadístico son de baja calidad. Hace falta unificar criterios y diseños de investigación con evidencia científica altamente recomendable, para que el uso del PRP como agente ortobiológico en estas patologías, pueda ser ampliamente aceptado.
 
Publisher EDIMECO S.A.
 
Date 2020-09-04
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://medicinaylaboratorio.com/index.php/myl/article/view/355
10.36384/01232576.355
 
Source Medicina & Laboratorio; Vol. 25 No. 1 (2021); 419-440
Medicina y Laboratorio; Vol. 25 Núm. 1 (2021); 419-440
2500-7106
0123-2576
 
Language spa
 
Relation https://medicinaylaboratorio.com/index.php/myl/article/view/355/335
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For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

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