Jurnal Ilmiah Manuntung

View Publication Info
 
 
Field Value
 
Title
OPTIMASI VARIASI KONSENTRASI LIPID TERHADAP KARAKTERISTIK FISIK SOLID LIPID NANOPARTICLE (SLN) GLIBENKLAMID



 
Creator Yusuf, Nurul Arfiyanti
Aksa, Rahmad
Cahyono, Fisa Juniawan
 
Description Glibenclamide is a sulfonylurea drug compound used as oral antidiabetic. Solid Lipid Nanoparticles (SLN) are alternative carrier systems that can be used to increase the bioavailability of drugs with low solubility. The purpose of this study was to determine the effect of lipid concentration on the efficiency of Solid Lipid Nanoparticle (SLN) entrapment efficiency of glibenclamide, to determine the optimum concentration of lipids which had the best Solid Lipid Nanoparticle (SLN) efficiency parameter values ​​of glibenclamide. This study varied between glyceryl monostearate and oleic acid as a lipid phase made in 12 formulas. The method of making solid lipid nanoparticles used by the solvent emulsion / evaporation method. The results of the study showed that the concentration variations between oleic acid lipids and glyceryl monostearate had a significant effect on percent entrapment efficiency in glibenclamide Solid Lipid Nanoparticle (SLN) preparations. The optimal formula is a formula with 1% oleic acid and 9% glyceryl monostearate which has particle size of 294.6 nm with a PI value (polydispersity index) of 0.465 .
 
Publisher jurnal ilmiah manuntung akademi farmasi samarinda
 
Date 2020-12-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://jurnal.akfarsam.ac.id/index.php/jim_akfarsam/article/view/341
10.51352/jim.v6i2.341
 
Source Jurnal Ilmiah Manuntung; Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung; 163-171
Jurnal Ilmiah Manuntung; Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung; 163-171
2477-1821
2443-115X
 
Language eng
 
Relation http://jurnal.akfarsam.ac.id/index.php/jim_akfarsam/article/view/341/178
 
Rights Copyright (c) 2020 Jurnal Ilmiah Manuntung
http://creativecommons.org/licenses/by-sa/4.0/
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library