Hibiscus sabdariffa shows the potential of downregulating the expression of the Kiss1 gene in the ovary of Wistar rats.

International Journal of Biomedical Research

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Field Value
 
Title Hibiscus sabdariffa shows the potential of downregulating the expression of the Kiss1 gene in the ovary of Wistar rats.
 
Creator Okafor, Izuchukwu Azuka
Nnamah, Uchenna Somtochukwu
Nweke, Johnson Okwudili
Nnaka, Jude Amechi
Ahiatrogah, Selasie
Okeke, Uche Valentine
 
Subject roselle
ovary
kiss1 gene
gene expression
hormones
antioxidant
histology
Hibiscus sabdariffa
 
Description Objectives: This study investigated the Kiss1 gene expression in the ovary, following the administration of Methanolic extract of Hibiscus sabdariffa (MEHS) in Wistar rats.
Methods: Fifteen (15) rats with an average weight of 148 g were randomly divided into three (3) groups (n=5), A-C. Group A was given no treatment and served as the normal control group. Groups B and C received oral administration of 200mg/kg and 400mg/kg of MEHS respectively. The extract was administered once a day for 21 days.
Result: No significant difference was observed in the relative ovarian weight, reproductive hormone levels, and ovarian antioxidant levels in all the treatment groups compared to the control (p>0.05). There is a significantly lower intensity of expression of the Kiss1 gene in the ovarian tissue of group C (p=0.011) when compared to the control group. There is no significant correlation between the relative intensity of Kiss1 gene expression in the ovary and the reproductive hormones of all the experimental groups (p =.879, .534, .133; r=.081, .322, -.686). MEHS caused no histopathological changes in the ovary at both treatment doses (200mg/kg and 400mg/kg).
Conclusion: MEHS shows the potential of downregulating the expression of the Kiss1 gene in the ovary, albeit at a higher dose. However, this effect lacks a regulatory mechanism on the reproductive hormones and ovarian antioxidative levels.
 
Publisher Scholar Science Journals
 
Date 2020-11-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://ssjournals.com/index.php/ijbr/article/view/5535
 
Source International Journal of Biomedical Research; Vol. 11 No. 11 (2020): Nov; e5535
0976-9633
2455-0566
 
Language eng
 
Relation http://ssjournals.com/index.php/ijbr/article/view/5535/3728
 
Rights Copyright (c) 2020 International Journal of Biomedical Research
http://creativecommons.org/licenses/by/4.0
 

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