Hibiscus sabdariffa shows the potential of downregulating the expression of the Kiss1 gene in the ovary of Wistar rats.
International Journal of Biomedical Research
View Publication Info| Field | Value | |
| Title |
Hibiscus sabdariffa shows the potential of downregulating the expression of the Kiss1 gene in the ovary of Wistar rats.
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| Creator |
Okafor, Izuchukwu Azuka
Nnamah, Uchenna Somtochukwu Nweke, Johnson Okwudili Nnaka, Jude Amechi Ahiatrogah, Selasie Okeke, Uche Valentine |
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| Subject |
roselle
ovary kiss1 gene gene expression hormones antioxidant histology Hibiscus sabdariffa |
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| Description |
Objectives: This study investigated the Kiss1 gene expression in the ovary, following the administration of Methanolic extract of Hibiscus sabdariffa (MEHS) in Wistar rats. Methods: Fifteen (15) rats with an average weight of 148 g were randomly divided into three (3) groups (n=5), A-C. Group A was given no treatment and served as the normal control group. Groups B and C received oral administration of 200mg/kg and 400mg/kg of MEHS respectively. The extract was administered once a day for 21 days. Result: No significant difference was observed in the relative ovarian weight, reproductive hormone levels, and ovarian antioxidant levels in all the treatment groups compared to the control (p>0.05). There is a significantly lower intensity of expression of the Kiss1 gene in the ovarian tissue of group C (p=0.011) when compared to the control group. There is no significant correlation between the relative intensity of Kiss1 gene expression in the ovary and the reproductive hormones of all the experimental groups (p =.879, .534, .133; r=.081, .322, -.686). MEHS caused no histopathological changes in the ovary at both treatment doses (200mg/kg and 400mg/kg). Conclusion: MEHS shows the potential of downregulating the expression of the Kiss1 gene in the ovary, albeit at a higher dose. However, this effect lacks a regulatory mechanism on the reproductive hormones and ovarian antioxidative levels. |
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| Publisher |
Scholar Science Journals
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| Date |
2020-11-30
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
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| Format |
application/pdf
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| Identifier |
http://ssjournals.com/index.php/ijbr/article/view/5535
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| Source |
International Journal of Biomedical Research; Vol. 11 No. 11 (2020): Nov; e5535
0976-9633 2455-0566 |
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| Language |
eng
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| Relation |
http://ssjournals.com/index.php/ijbr/article/view/5535/3728
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| Rights |
Copyright (c) 2020 International Journal of Biomedical Research
http://creativecommons.org/licenses/by/4.0 |
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