Merokok dan Oksidasi DNA

Sains Medika

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Field Value
 
Title Merokok dan Oksidasi DNA
 
Creator Fitria, Fitria
Triandhini, R.I.N.K Retno
Mangimbulude, Jubhar C.
Karwur, Ferry Fredy
 
Subject 8-oxoguanosine; DNA damage; free radicals; mutations; oxidative stress
 
Description Cigarette smoke consists of a mix of chemical substances in the form of gases and dispersed particles. Recently, more than 4000 compounds presented incigarette smoke have been isolated. Most of these compounds are toxic to our body’s cells. Toxic gases including carbon monoxide (CO), hydrogen cyanide(HCN), nitrogen oxides, and volatile chemicals such as nitrosamines, formaldehyde are found in in cigarette smoke. besides toxic compounds, cigarettesmoke also containsfree radicalsincluding peroxynitrite, hydrogen peroxide, and superoxide. These free radicals may accelerate cellular damage due tooxidative stress. Targets od free radical attacks include DNA, protein and lipids. The harmful chemicals in form of gases and volatile substances in cigarettescause multiple genetic mutations. the combination of genetic mutations and DNA damage lead to genetic instability and it may cause cancer. OxidativeDNA damage caused by cigarette smoke can be identified with the presence of 8-oxoguanosine used as one of the biomarkers for oxidative DNA damage.Increased concentration of 8-oxoguanosine in DNA has an important role in carcinogenesis and triggers tumor cells. both active and passive smokers havebeen reported to have an elevated concentration of 8-oxoguanosine in their lung tissue and peripheral leukocytes as well as for passive smokers. This paperprovide informations and understanding of the effects of smoking on the genetic stability, especially in the DNA molecule.
 
Publisher Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)
 
Contributor
 
Date 2013-12-09
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/352
 
Source Sains Medika; Vol 5, No 2 (2013): July-December 2013; 113-120
2339-093X
2085-1545
 
Language eng
 
Relation http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/352/291
 

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