Effect of White Turmeric Extract (Curcuma zedoaria) Using Zam-zam Solvent Compare with Ethanol Solvent Against Breast Cancer Cell T47D

Sains Medika

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Title Effect of White Turmeric Extract (Curcuma zedoaria) Using Zam-zam Solvent Compare with Ethanol Solvent Against Breast Cancer Cell T47D
Creator Hudaya, Isna
Nasihun, Taufiqurrahman
Sumarawati, Titiek
Subject T47D; Cytotoxicity; Curcuma, Zedoaria; Zam-zam
Description Introduction: Curcuma zedoaria is one of the herbal plants potentially protects and cures many diseases, particularly as anti-cancer and anti-tumor. Anti-cancer active compounds of it are flavonoid, phenolic, and saponin. Objectives: This study aimed to explore the cytotoxicity of Curcuma zedoria extract (CZE). Methods: Experimental Quasi with post test non equivalent control group design on T47D cell line at Biology laboratory, Faculty of Medicine, Sultan Agung Islamic University, Semarang. The research was consisted of 2 groups, namely: intervention group with CZE zam-zam solvent and intervention group with CZE ethanol solvent given 10 different dosages each for 1.000 μg/mL; 500 μg/mL; 250 μg/mL; 125 μg/mL; 62.5 μg/mL; 31.25 μg/mL; 15.62 μg/mL; 7.81 μg/mL; 3.90 μg/mL; 1.95 μg/mL. Cytotoxicity test of IC50 using direct counting method and analyzed by probit analysis. Results: IC50 value of CZE in zam-zam and ethanol solvent were 28.24 μg/ml and 13.71 µg/ml respectively at the same 24 hours incubation period. Chi-square test revealed p value was 0.000 (α = 0.05), meaning that there was significant relationship. Conclusion: CZE activity using ethanol is highly active while CZE using zam-zam water is moderate and both of them have the toxicity on breast cancer cell. As the result, apoptosis process may occur.
Publisher Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)
Date 2016-01-04
Type info:eu-repo/semantics/article

Format application/pdf
Identifier http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/601
Source Sains Medika; Vol 6, No 2 (2015): July-December 2015; 52-55
Language eng
Relation http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/601/532
Rights Copyright (c) 2016 Sains Medika

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