TERAPI ANTIVIRAL PADA SIROSIS HATI DEKOMPENSATA TERKAIT INFEKSI VIRUS HEPATITIS B

Majalah Kedokteran Andalas

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Field Value
 
Title TERAPI ANTIVIRAL PADA SIROSIS HATI DEKOMPENSATA TERKAIT INFEKSI VIRUS HEPATITIS B
 
Creator Fadrian, Fadrian; Bagian Penyakit Dalam RS dr. M. Djamil Padang/Fakultas Kedokteran Universitas Andalas
 
Subject Medicine
antiviral; sirosis hati dekompensata; hepatitis B
 
Description Hepatitis B masih merupakan masalah kesehatan global. Diperkirakan sekitar 2 miliar penduduk dunia pernah terpapar virus hepatitis B (VHB) dan lebih dari 350 juta diantaranya menjadi kronik. Sirosis hati, gagal hati, dan karsinoma hati dapat terjadi pada 15-40% penderita dengan infeksi virus hepatitis B kronik. Pada saat ini sekitar 1 juta kematian per tahun akibat penyakit hati berhubungan dengan VHB. Terapi antiviral pada sirosis hati dekompensata terkait VHB merupakan suatu tantangan dalam pengobatan. Tujuan terapi pada pasien sirosis hati dekompensata terkait VHB diantaranya penekanan replikasi virus, serokonversi HBeAg, pembalikan dekompensasi hati, dan pengurangan risiko kanker hati. Terapi antiviral diindikasikan pada semua pasien sirosis hati dekompensata jika DNA VHB terdeteksi, terlepas dari kadar ALT atau status HBeAg. Terapi antiviral pilihan adalah nucleosida/tida analog, seperti lamivudine, telbivudine, adefovir dipifoxil, tenofovir, entecavir. Lama pengobatan biasanya seumur hidup, dan penghentian terapi dipertimbangkan apabila terdapat risiko reaktivasi virus, perburukan dekompensasi hati, dan regresi histologis.
 
Publisher Faculty of Medicine Andalas University
 
Contributor
 
Date 2016-04-28
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://jurnalmka.fk.unand.ac.id/index.php/art/article/view/442
10.22338/mka.v39i1.442
 
Source Majalah Kedokteran Andalas; Vol 39, No 1: April 2016; 35-41
2442-5230
0126-2092
 
Language eng
 
Relation http://jurnalmka.fk.unand.ac.id/index.php/art/article/view/442/269
 
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