ANALISIS EKSPRESI TRANSPORTER ZINK (ZNT-1) SEBAGAI FAKTOR PROGNOSIS ADENOKARSINOMA PROSTAT

Majalah Kedokteran Andalas

View Publication Info
 
 
Field Value
 
Title ANALISIS EKSPRESI TRANSPORTER ZINK (ZNT-1) SEBAGAI FAKTOR PROGNOSIS ADENOKARSINOMA PROSTAT
 
Creator Utomo, Feriandri; Faculty of Medicine and Health Science Abdurrab University
Siregar, Nurjati Chairani; Department of Pathology, Faculty of Medicine Univesity of Indonesia
Kodariah, Ria; Department of Pathology, Faculty of Medicine Univesity of Indonesia
 
Subject Medicine
ZnT-1; ZIP-1; Caspase-3; adenokarsinoma prostat; skor Gleason
 
Description Penurunan kadar Zink (Zn) berkorelasi dengan peningkatan skor Gleason adenokarsinoma prostat, dan rendahnya Caspase-3 (eksekutor apoptosis). Ekspresi ZIP-1 (importer Zn) turun pada adenokarsinoma prostat. Korelasi ZnT-1 (eksporter Zn), ZIP-1 dan Caspase-3 diduga berpotensi menjadi faktor prognosis adenokarsinoma prostat. Penelitian ini bertujuan menganalisis korelasi ekspresi ZnT-1, ZIP-1, Caspase-3 dan skor Gleason adenokarsinoma prostat. Studi retrospektif analitik potong lintang dilakukan pada 14 kasus adenokarsinoma prostat skor Gleason ≤7 dan 16 kasus dengan skor Gleason >7. Ekspresi ZnT-1 dinilai dengan metode imunohistokimia. Analisis tambahan dilakukan untuk melihat korelasi ZnT-1, ZIP-1 dan Caspase-3. Hasil penelitian didapatkan ZnT-1 pada skor Gleason >7 lebih rendah daripada skor Gleason ≤7. ZnT-1 berkorelasi dengan skor Gleason. ZnT-1 berkorelasi dengan ZIP-1 pada skor Gleason >7. ZIP-1 berkorelasi dengan Caspase-3 pada skor Gleason ≤7. ZIP-1 berkorelasi kuat dengan Caspase-3 pada skor Gleason 8. Penelitian ini menyimpulkan rendahnya ekspresi ZnT-1 dan ZIP-1 berpotensi menjadi faktor prognosis adenokarsinoma prostat.
 
Publisher Faculty of Medicine Andalas University
 
Contributor
 
Date 2016-04-28
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://jurnalmka.fk.unand.ac.id/index.php/art/article/view/440
10.22338/mka.v39i1.440
 
Source Majalah Kedokteran Andalas; Vol 39, No 1: April 2016; 11-20
2442-5230
0126-2092
 
Language eng
 
Relation http://jurnalmka.fk.unand.ac.id/index.php/art/article/view/440/267
 
Rights Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2016 Simon Fraser University Library