Lipolysis stimulating peptides of potato protein hydrolysate effectively suppresses high-fat-diet-induced hepatocyte apoptosis and fibrosis in aging rats

Food & Nutrition Research

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Title Lipolysis stimulating peptides of potato protein hydrolysate effectively suppresses high-fat-diet-induced hepatocyte apoptosis and fibrosis in aging rats
 
Creator Chiang, Wen-Dee
Huang, Chih-Yang
Paul, Catherine Reena
Lee, Zong-Yan
Lin, Wan-Teng
 
Description Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common outcomes of obesity and is characterized by the accumulation of triglycerides, increased tissue apoptosis, and fibrosis. NAFLD is more common among elderly than in younger age groups, and it causes serious hepatic complications.Objective: In this study, alcalase treatment derived potato protein hydrolysate (APPH) with lipolysis-stimulating property has been evaluated for its efficiency to provide hepato-protection in a high-fat-diet (HFD)-fed aging rats.Design: Twenty-four-month-old SD rats were randomly divided into six groups (n=8): aged rats fed with standard chow, HFD-induced aged obese rats, HFD with low-dose (15 mg/kg/day) APPH treatment, HFD with moderate (45 mg/kg/day) APPH treatment, HFD with high (75 mg/kg/day) APPH treatment, and HFD with probucol.Results: APPH was found to reduce the NAFLD-related effects in rat livers induced by HFD and all of the HFD-fed rats exhibited heavier body weight than those with control chow diet. However, the HFD-induced hepatic fat accumulation was effectively attenuated in rats administered with low (15 mg/kg/day), moderate (45 mg/kg/day), and high (75 mg/kg/day) doses of APPH. APPH oral administration also suppressed the hepatic apoptosis- and fibrosis-related proteins induced by HFD.Conclusions: Our results thus indicate that APPH potentially attenuates hepatic lipid accumulation and anti-apoptosis and fibrosis effects in HFD-induced rats. APPH may have therapeutic potential in the amelioration of NAFLD liver damage.Keywords: apoptosis; fibrosis; high fat diet; lipolysis stimulating protein hydrolysates; obesity; APPH(Published: 12 July 2016)Citation: Food & Nutrition Research 2016, 60: 31417 - http://dx.doi.org/10.3402/fnr.v60.31417
 
Publisher Swedish Nutrition Foundation
 
Date 2016-07-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Animal Study
 
Format application/pdf
text/html
application/epub+zip
application/xml
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/vnd.openxmlformats-officedocument.wordprocessingml.document
 
Identifier https://foodandnutritionresearch.net/index.php/fnr/article/view/1001
10.3402/fnr.v60.31417
 
Source Food & Nutrition Research; Vol. 60 (2016)
1654-661X
1654-6628
 
Language eng
 
Relation https://foodandnutritionresearch.net/index.php/fnr/article/view/1001/3854
https://foodandnutritionresearch.net/index.php/fnr/article/view/1001/3855
https://foodandnutritionresearch.net/index.php/fnr/article/view/1001/3856
https://foodandnutritionresearch.net/index.php/fnr/article/view/1001/3857
https://foodandnutritionresearch.net/index.php/fnr/article/view/1001/3858
https://foodandnutritionresearch.net/index.php/fnr/article/view/1001/3859
https://foodandnutritionresearch.net/index.php/fnr/article/view/1001/3860
https://foodandnutritionresearch.net/index.php/fnr/article/view/1001/3861
 

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