Managing vascular risk factors among obese quitters with diabetes: how intensive lifestyle intervention and novel pharmacotherapy can work in concert?

British Journal of Diabetes

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Field Value
 
Title Managing vascular risk factors among obese quitters with diabetes: how intensive lifestyle intervention and novel pharmacotherapy can work in concert?
 
Creator Kar, Debasish; Leicester Diabetes Centre, University of Leicester AND Derbyshire Community Health Services NHS Foundation Trust
Seidu, Samuel; Leicester Diabetes Research Centre, University of Leicester.
Davies, Melanie; Leicester Diabetes Research Centre, University of Leicester
Khunti, Kamlesh; Leicester Diabetes Centre, University of Leicester
 
Subject Diabetes; Metabolism; Obesity; Smoking Cessation
Diabetes Mellitus, vascular risk factors, multifactorial intervention, pharmacotherapy.
 
Description  Obese smokers with diabetes are a special risk category for all-cause mortality and major adverse cardiovascular events (MACE). Weight loss and smoking cessation are key interventions advocated for the management of diabetes in almost all the guidelines across the globe. However, there is a substantial risk of weight gain following smoking cessation which may, in some cases, cause a transient worsening of glycaemic control in people with diabetes. The risk of weight gain and the potential for worsening of HbA1c may put off some obese smokers to quit. The cardiometabolic sequelae of smoking cessation in people with and without diabetes are different. The benefit of smoking cessation, in terms of reduced cardiovascular and all-cause mortality, in people without diabetes is evident within three years of quitting. However, it may take up to 10 years for people with diabetes to get this benefit. Post-cessation weight gain is much more detrimental to obese quitters with diabetes than those without. The aim of this review is to explore how best these high-risk individuals can be supported to remain abstinent long-term, and manage their vascular risk profile proactively, by concerted lifestyle intervention with judicious use of new and novel pharmacotherapy.
 
Publisher ABCD (Diabetes Care) Ltd
 
Contributor Leicester Diabetes Research Centre, Derbyshire Community Health Services NHS Foundation Trust
 
Date 2017-03-21
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format text/html
application/pdf
 
Identifier http://www.bjd-abcd.com/index.php/bjd/article/view/197
10.15277/bjd.2017.120
 
Source British Journal of Diabetes; Vol 17, No 1 (2017); 19-23
2397-6241
2397-6233
 
Language eng
 
Relation http://www.bjd-abcd.com/index.php/bjd/article/view/197/372
http://www.bjd-abcd.com/index.php/bjd/article/view/197/373
 
Coverage United Kingdom; Worldwide


 
Rights Copyright (c) 2017 British Journal of Diabetes
 

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