Karakterisasi Mutu Ekstrak Daun Sirsak (Annona muricata L.) dari Tiga Tempat Tumbuh

Buletin Penelitian Kesehatan

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Title Karakterisasi Mutu Ekstrak Daun Sirsak (Annona muricata L.) dari Tiga Tempat Tumbuh
 
Creator Setyorini, Herni Asih
Kurniatri, Arifayu Addiena; Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Jl. Percetakan Negara 23 Jakarta, 10560 Indonesia
Adelina, Rosa; Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Jl. Percetakan Negara 23 Jakarta, 10560 Indonesia
Adelina, Adelina; Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Jl. Percetakan Negara 23 Jakarta, 10560 Indonesia
 
Subject
 
Description Abstract The soursop leaves (Annona muricata L.) are part of soursop plants that have a potential to be developed as anticancer as it contains annonacin. Annonacin is one of the acetogenins compounds group that are cytotoxic and mostly can be found in soursop plants. In the development of pharmaceutical preparation, apart from their safety and efficacy, quality of medicinal raw materials has been one of the important factors. Soursop leaf extract quality can be affected by their types of growing places. Therefore, the research of the quality characterization of soursop leaf extracts from three different growing places needs to be done in order to identify the quality of the extract used as herbal medicines. Quality inspection of soursop leaf extracts was including non-specific and specific parameters. Soursop leaf samples were obtained from three growing places with different altitude, which were from Tawangmangu, Central Java,; Pasuruan, East Java; and Bogor, West Java.The results showed that the best leaf extracts of soursop was from Pasuruan with non-specific parameters: (water content of 7,15% , ash content of 3,59% and 0,44 ppb levels of aflatoxin G2, and specific parameters: (the concentration of annonacin is 12,80%). Keywords: soursop leaf, annonacin, characterization, quality extractsAbstrakDaun sirsak (Annona muricata L.) merupakan bagian dari tanaman sirsak yang berpotensi untuk dikembangkan sebagai antikanker karena mengandung annonacin. Annonacin adalah salah satu senyawa golongan acetogenins yang bersifat sitotoksik dan paling banyak terkandung dalam tanaman sirsak. Dalam pengembangan sediaan obat, mutu bahan baku obat merupakan salah satu faktor penting, selain keamanan dan efektifitas. Mutu ekstrak daun sirsak dapat dipengaruhi oleh perbedaan tempat tumbuh. Oleh karena itu, penelitian karakterisasi terhadap mutu ekstrak daun sirsak pada tiga tempat tumbuh perlu dilakukan untuk mengidentifikasi mutu ekstrak yang digunakan sebagai obat herbal. Pemeriksaan mutu ekstrak daun sirsak mencakup parameter non spesifik dan spesifik. Sampel daun sirsak diperoleh dari tiga tempat tumbuh dengan ketinggian yang berbeda, yaitu daerah Tawangmangu, Jawa Tengah; Pasuruan, Jawa Timur; dan Bogor, Jawa Barat. Hasil penelitian menunjukkan bahwa ekstrak daun sirsak yang paling baik adalah ekstrak dari daerah Pasuruan dengan parameter non spesifik: (kadar air 7,15%, kadar abu 3,59%, kadar aflatoksin G2 0,44 ppb), dan parameter spesifik: (kadar annonacin sebesar 12,80%).Kata kunci: daun sirsak , annonacin, karakterisasi, mutu ekstrak
 
Publisher Badan Penelitian dan Pengembangan Kesehatan
 
Contributor
 
Date 2016-12-30
 
Type
 
Format application/pdf
 
Identifier http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/view/5184
10.22435/bpk.v44i4.5184.279-286
 
Source Buletin Penelitian Kesehatan; Vol 44, No 4 (2016); 279-286
Buletin Penelitian Kesehatan; Vol 44, No 4 (2016); 279-286
 
Language id
 
Relation http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/5184/8982
 
Rights The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development) as publisher of the journal.Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development).Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal.
 

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