Gambaran Peningkatan Kadar Inter Leukin-10 (IL-10) dan Tumor Necrosis Faktor – Alfa (TNF-α) dengan Gejala Klinis pada Penderita Malaria

Buletin Penelitian Kesehatan

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Title Gambaran Peningkatan Kadar Inter Leukin-10 (IL-10) dan Tumor Necrosis Faktor – Alfa (TNF-α) dengan Gejala Klinis pada Penderita Malaria
 
Creator Mau, S.Si, M,Sc, Fridolina; Loka Litbang P2B2 Waikabubak
Tallan, Mefi Mariana; Loka Penelitian dan Pengembangan Pengendalian Penyakit Bersumber Binatang Waikabubak, Jln. Basuki Rahmat Km 5 Puu Weri, Waikabubak, Nusa Tenggara Timur Indonesia
 
Subject clinical symptom, cytokine TNF-α, IL-10, malaria
 
Description Abstract Malaria parasites develop in erythrocytes and naturally-acquired immune responses can result in either the elimination of the parasites or a persistent response. The cytokines are responsible for all the symptoms, pathological alterations and the outcome of the infection depending on the reciprocal regulation of the pro inflammatory (TNF-α) and anti-inflammatory (IL-10) cytokines. The aim of this study was to describe the level of IL-10 and TNF- α on malaria infection, using an analytic laboratory cross-sectional design. The serum levels of the cytokines TNF- α and IL-10 from 50 patients were evaluated by indirect ELISA. The results revealed that increased levels of IL-10 and TNF-α among respondents without clinical symptoms of malaria were higher compared to respondents with clinical symptoms of P. falciparum and P. vivax. Statistically, there was no significant association between clinical symptoms with increased cytokine IL-10 and TNF-α.The ratio of TNF-α / IL-10 in respondents with clinical symptoms and without clinical symptoms indicated that the respondent without clinical symptoms was higher than that of clinical symptoms. The study concluded that molecular basis of immune response of patients in the study site is still very good because of reciprocal response between pro-inflammatory cytokines and anti-inflammatory. Key words : clinical symptom, cytokine TNF-α, IL-10, malaria AbstrakKetika parasit berkembang di dalam sel darah merah, respon kekebalan tubuh yang secara alami diperoleh dapat mengakibatkan penghapusan/pembersihan parasit atau respon persisten dimediasi oleh sitokin yang mengarah ke immunopatologi. Sitokin yang ikut bertanggung jawab untuk semua gejala, perubahan patologi yang dihasilkan tergantung pada hubungan timbal balik antara sitokin pro inflamsi (TNF-α) dan anti inflamasi (IL-10). Tujuan penelitian adalah menggambarkan peningkatan kadar IL-10 dan TNF-α pada malaria. Metode penelitian ini menggunakan rancangan analitik laboratorium secara potong lintang. Kadar TNF-α dan IL-10 diukur dengan menggunakan metode ELISA. Hasil; peningkatan kadar IL-10 dan kadar TNF-α pada responden malaria tanpa gejala klinis lebih tinggi dibandingkan dengan responden dengan gejala klinis P. falciparum maupun P.vivax. Secara statistik tidak ada hubungan signifikan antara gejala klinis dengan peningkatan sitokin IL-10 dan TNF-α. Rasio TNF-α/IL-10 pada responden dengan gejala klinis dan tanpa gejala klinis menunjukkan pada responden tanpa gejala klinis lebih tinggi dibandingkan dengan gejala klinis. Kesimpulan : Secara molekuler respon immun penderita di lokasi penelitian masih sangat baik dimana masih ada respon timbal balik antara sitokin pro-inflamasi dan anti- inflamasi.Kata kunci : gejala klinis, malaria, sitokin TNF-α, IL-10
 
Publisher Badan Penelitian dan Pengembangan Kesehatan
 
Contributor
 
Date 2016-12-28
 
Type
 
Format application/pdf
 
Identifier http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/view/4806
10.22435/bpk.v44i3.4806.181-186
 
Source Buletin Penelitian Kesehatan; Vol 44, No 3 (2016); 181-186
Buletin Penelitian Kesehatan; Vol 44, No 3 (2016); 181-186
 
Language id
 
Relation http://ejournal.litbang.kemkes.go.id/index.php/BPK/article/downloadSuppFile/4806/7714
 
Rights The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development) as publisher of the journal.Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development).Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal.
 

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