Appropriate use of antifungal agents

Reviews in Health Care

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Title Appropriate use of antifungal agents
Creator Castagnola, Elio
Fungal infections; Off-label use; Unauthorized use; Exceptional use; Authorizations
Description As knowledge increases faster and faster, authorizations for drug use often don’t report the most recent evidence. In addition, trials on pediatric populations are rare: as a consequence, a lot of drugs in pediatrics are prescribed out of their indications. This is called off-label use, if the drug isn’t approved for the treatment of a specific disease, or unauthorized use, if, for example, a dose isn’t written in the summary of product characteristics. These uses aren’t illegal, but physicians should take some steps in order to protect their liability: for example, the hospital should write documents based on shared scientific evidence, where the reasons supporting a choice are explained. Informed consent should be obtained, after an exhaustive explanation, from the parents. There is also the exceptional use, i.e. the use in desperate cases, where no other treatments are possible, but, for example, a study in an animal model has resulted in good outcomes. Even in this case, similar measures should be taken by the physician.
Publisher SEEd
Contributor Il presente Congress Report è stato supportato da Astellas Pharma SpA
Date 2013-07-11
Type info:eu-repo/semantics/article

Format text/html
Source Reviews in Health Care; Vol 4, No 1S (2013); 67-71
Language eng

Rights Copyright (c) 2013 Seed

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