Hepatitis B Infection and pregnancy: disease management and prevention of perinatal transmission

Reviews in Health Care

View Publication Info
 
 
Field Value
 
Title Hepatitis B Infection and pregnancy: disease management and prevention of perinatal transmission
 
Creator Perricone, Giovanni
Vinci, Maria
 
Subject
Chronic hepatitis B virus; Perinatal transmission; Antiviral drugs
 
Description Chronic hepatitis B virus (HBV) infection affects about 350 million individuals worldwide. Perinatal transmission is a common mode of HBV transmission. Without prophylaxis the risk of mother-to-child transmission is very high and it depends on the HBeAg status of mothers, being 85%-90% for HBeAg-positive mothers, and 32% for HBeAg-negative mothers. Maternal screening programs aimed at identifying HBsAg-positive mothers should be part of pregnancy routine examinations. Once HBsAg-positive mothers are identified, their babies receive passive-active immunoprophylaxis at birth, this reduces the risk of vertical HBV transmission from 90% to 5-10%. The present review aimed to show the peculiar and sometimes controversial aspects which concern both the mother and the fetus in the case of HBV infection in pregnancy, including the effect of pregnancy on HBV infection and of HBV infection on pregnancy; the potential viral transmission from mother to newborn; and prevention of mother-to-child transmission through antiviral drugs, and the type of antiviral drug to use considering their efficacy and potential teratogenic effect.
 
Publisher SEEd
 
Contributor La presente review è stata realizzata con il supporto di Gilead Sciences
 
Date 2014-07-11
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion


 
Format text/html
application/pdf
 
Identifier https://journals.edizioniseed.it/index.php/rhc/article/view/923
10.7175/rhc.v5i1S.923
 
Source Reviews in Health Care; Vol 5, No 1S (2014); 5-18
2038-6702
2038-6699
 
Language eng
 
Relation https://journals.edizioniseed.it/index.php/rhc/article/view/923/1108
https://journals.edizioniseed.it/index.php/rhc/article/view/923/1109
 
Coverage


 
Rights Copyright (c) 2014 Seed
http://creativecommons.org/licenses/by-nc/4.0
 

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