Antifungal agents in non-neonatologic pediatrics

Reviews in Health Care

View Publication Info
 
 
Field Value
 
Title Antifungal agents in non-neonatologic pediatrics
 
Creator Castagnola, Elio
 
Subject
Fungal infections; Antifungal agents; Pharmacokinetics; MIC; Penetration; Interactions; Fungicidal; Fungistatic
 
Description The spectrum of action of antifungal agents helps driving the choice of the treatment, basing on the activity against the fungus of interest. Pharmacokinetics should also be taken into account, considering the time-dependent and the concentration-dependent drugs. Triazoles belong to the first group, while amphotericin B and echinocandins belong to the second one. The effectiveness of time-dependent drugs hangs on the time spent above the Minimal Inhibitory Concentration (MIC), whereas that of concentration-dependent drugs is related to the peak of concentration achieved. Thetissue penetration is another important factor that should be taken into account while prescribing an antifungal agent. Interactions with other drugs, above all with those used to treat underlying pathologies, should also be considered. Fungicidal drugs are generally preferred to fungistatic agents, therefore echinocandins and amphotericin B are more prescribed than azoles. Combination therapies are not recommended.
 
Publisher SEEd
 
Contributor Il presente Congress Report è stato supportato da Astellas Pharma SpA
 
Date 2013-07-11
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion


 
Format text/html
application/pdf
 
Identifier https://journals.edizioniseed.it/index.php/rhc/article/view/860
10.7175/rhc.v4i1S.860
 
Source Reviews in Health Care; Vol 4, No 1S (2013); 45-50
2038-6702
2038-6699
 
Language eng
 
Relation https://journals.edizioniseed.it/index.php/rhc/article/view/860/950
https://journals.edizioniseed.it/index.php/rhc/article/view/860/951
 
Coverage


 
Rights Copyright (c) 2013 Seed
http://creativecommons.org/licenses/by-nc/4.0
 

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