Antifungal agents in non-neonatologic pediatrics

Reviews in Health Care

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Title Antifungal agents in non-neonatologic pediatrics
Creator Castagnola, Elio
Fungal infections; Antifungal agents; Pharmacokinetics; MIC; Penetration; Interactions; Fungicidal; Fungistatic
Description The spectrum of action of antifungal agents helps driving the choice of the treatment, basing on the activity against the fungus of interest. Pharmacokinetics should also be taken into account, considering the time-dependent and the concentration-dependent drugs. Triazoles belong to the first group, while amphotericin B and echinocandins belong to the second one. The effectiveness of time-dependent drugs hangs on the time spent above the Minimal Inhibitory Concentration (MIC), whereas that of concentration-dependent drugs is related to the peak of concentration achieved. Thetissue penetration is another important factor that should be taken into account while prescribing an antifungal agent. Interactions with other drugs, above all with those used to treat underlying pathologies, should also be considered. Fungicidal drugs are generally preferred to fungistatic agents, therefore echinocandins and amphotericin B are more prescribed than azoles. Combination therapies are not recommended.
Publisher SEEd
Contributor Il presente Congress Report è stato supportato da Astellas Pharma SpA
Date 2013-07-11
Type info:eu-repo/semantics/article

Format text/html
Source Reviews in Health Care; Vol 4, No 1S (2013); 45-50
Language eng

Rights Copyright (c) 2013 Seed

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