Efficacy and safety of bevacizumab and etoposide combination in patients with recurrent malignant gliomas who have failed bevacizumab

Reviews in Health Care

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Field Value
 
Title Efficacy and safety of bevacizumab and etoposide combination in patients with recurrent malignant gliomas who have failed bevacizumab
 
Creator Carrillo, Jose A.
Hsu, Frank P.K.
Delashaw, Johnny
Bota, Daniela
 
Subject Neurology, Onclolgy
Bevacizumab; Etoposide; Malignant Gliomalioblastoma Multiforme, Malignant Glioma, GBM
 
Description Despite recent advances in the treatment of malignant gliomas (World Health Organization grade III and grade IV tumors- Glioblastoma Multiforme, Anaplastic Astrocytoma and Anaplastic Oligodendroglioma), the overall prognosis remains poor. Tumor recurrence in malignant glioma is inevitable, and associated with reduced overall survival (OS). Bevacizumab is approved for use in progressive GBM as a second line treatment, and is associated with improvements in progression free survival (PFS). However, all GBM patients eventually recur on bevacizumab therapy, with a very short OS after bevacizumab failure. No FDA-approved therapy is available for this clinical setting. Etoposide crosses the blood-brain barrier and has activity in recurrent malignant gliomas. The use of bevacizumab with etoposide in recurrent malignant gliomas in the setting of bevacizumab resistance is evaluated in this review. Bevacizumab and etoposide combined therapy is associated with radiographic response and effectiveness in selected patients.
 
Publisher SEEd
 
Contributor
 
Date 2014-01-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

narrative
 
Format text/html
application/pdf
 
Identifier https://journals.edizioniseed.it/index.php/rhc/article/view/668
10.7175/rhc.v5i1.668
 
Source Reviews in Health Care; Vol 5, No 1 (2014); 23-32
2038-6702
2038-6699
 
Language eng
 
Relation https://journals.edizioniseed.it/index.php/rhc/article/view/668/1040
https://journals.edizioniseed.it/index.php/rhc/article/view/668/1041
 
Coverage


 
Rights Copyright (c) 2014 Seed
http://creativecommons.org/licenses/by-nc/4.0
 

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