Lower is better: ezetimibe and PCSK9 inhibition join the mainstream of lipid‑lowering therapy

Reviews in Health Care

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Field Value
 
Title Lower is better: ezetimibe and PCSK9 inhibition join the mainstream of lipid‑lowering therapy
 
Creator Wójcik, Cezary
 
Subject
Dyslipidemia; PCSK9 inhibitors; Ezetimibe; LDL; Clinical lipidology
 
Description The focus of 2013 cholesterol guidelines to prevent atherosclerotic cardiovascular disease (ASCVD) released by American College of Cardiology (ACC) and American Heart Association (AHA) is the administration of high intensity statin therapy to specific four groups of patients, which were found to benefit the most from such therapy. They no longer promote achieving specific LDL-C goals with a combination therapy involving statins and other drugs, as advocated by the former ATP-III guidelines as well as current guidelines of European Atherosclerosis Society, International Atherosclerosis Society or National Lipid Association. Such approach has been dictated by the strict reliance on randomized controlled trials as the only acceptable level of evidence. However, since publication of the 2013 ACC/AHA guidelines, cardiovascular benefits of ezetimibe added to statin therapy have been established. Moreover, the advent of PCSK9 inhibitors, providing a powerful supplement and/or alternative to statin therapy, further complicates the therapeutic horizon in dyslipdiemias. It is very likely that a new set of ACC/AHA guidelines will be published in 2016, with a return of specific LDL-C and Non-HDL-C goals of therapy as well as integration of drugs other than statins. As the treatment of dyslipidemias becomes more complex, the need for the subspecialty of clinical lipidology to be officially recognized becomes more evident.
 
Publisher SEEd
 
Contributor
 
Date 2016-09-16
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion


 
Format text/html
application/pdf
 
Identifier https://journals.edizioniseed.it/index.php/rhc/article/view/1263
10.7175/rhc.v7i1.1263
 
Source Reviews in Health Care; Vol 7, No 1 (2016); 17-25
2038-6702
2038-6699
 
Language eng
 
Relation https://journals.edizioniseed.it/index.php/rhc/article/view/1263/1567
https://journals.edizioniseed.it/index.php/rhc/article/view/1263/1568
 
Coverage


 
Rights http://creativecommons.org/licenses/by-nc/4.0
 

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