Bivalirudin in the Treatment of Coronary Artery Disease

Reviews in Health Care

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Title Bivalirudin in the Treatment of Coronary Artery Disease
Creator Jayasinghe, Rohan
Maxwell, Ryan
Sridhar, Vaishnavi
Bivalirudin; Direct Thrombin Inhibitors; Anticoagulants; Acute Coronary Syndromes
Description Periprocedural anticoagulation continues to be a vital aspect in the management of coronary artery disease. Bivalirudin is a relatively new drug that has caught much attention in the last decade, especially in the context of percutaneous coronary intervention for acute coronary syndromes. Multiple clinical trials have shown the efficacy, safety profile and limitations of bivalirudin in contrast to previously used heparin and glycoprotein IIb/IIIa inhibitors. These trials have included patients with moderate to high-risk stable angina, unstable angina, non-ST-elevation and ST-elevation myocardial infarctions requiring PCI. The growing body of evidence on bivalirudin has also improved the understanding of its applicability and efficacy over other hirudin-based anticoagulants, however continual review of more recent evidence is important in order to integrate bivalirudin more widely across the various guidelines. This article aims to study the cross-section of the evidence base to date on the clinical use, efficacy and risks related to the use of bivalirudin and attempts to provide the clinician with a practical overview of the role of bivalirudin in the most recent guidelines.
Publisher SEEd
Contributor RJ has received advisory honoraria from The Medicines company. RM and VS have no conflicts of interest
Date 2014-04-29
Type info:eu-repo/semantics/article

Format text/html
Source Reviews in Health Care; Vol 5, No 2 (2014); 67-80
Language eng

Rights Copyright (c) 2014 Seed

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