Metformin in advanced chronic kidney disease: are current guidelines overly restrictive?

British Journal of Diabetes

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Field Value
 
Title Metformin in advanced chronic kidney disease: are current guidelines overly restrictive?
 
Creator Cole, Nicholas I; South West Thames Renal Department, Epsom and St Helier University Hospitals, Surrey, UK
Swift, Pauline A; South West Thames Renal Department, Epsom and St Helier University Hospitals, Surrey, UK
Suckling, Rebecca J; South West Thames Renal Department, Epsom and St Helier University Hospitals, Surrey, UK
Andrews, Peter A; South West Thames Renal Department, Epsom and St Helier University Hospitals, Surrey, UK
 
Subject
type 2 diabetes mellitus, chronic kidney disease, metformin, biguanides, lactic acidosis, lactate, cardiovascular disease, hypoglycaemia
 
Description Type 2 diabetes mellitus and chronic kidney disease (CKD) frequently co-exist and the increasing burden of both conditions is a global concern. Metformin is established as the first-line treatment for type 2 diabetes because it is associated with improved cardiovascular outcomes and a reduced risk of hypoglycaemia compared with other treatment options. Patients with CKD may benefit in particular because they are at high risk of both cardiovascular disease and hypoglycaemic episodes. However, the use of metformin is restricted in this population due to the concerns over lactic acidosis. Recent reviews have evaluated this risk and concluded that current guidelines for prescribing metformin in CKD may be too restrictive. This narrative review considers this evidence further, but also examines the strength of evidence that favours the use of metformin in CKD patients.
 
Publisher ABCD (Diabetes Care) Ltd
 
Contributor
 
Date 2016-12-20
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format text/html
application/pdf
 
Identifier http://www.bjd-abcd.com/index.php/bjd/article/view/202
10.15277/bjd.2016.106
 
Source British Journal of Diabetes; Vol 16, No 4 (2016); 168-175
2397-6241
2397-6233
 
Language eng
 
Relation http://www.bjd-abcd.com/index.php/bjd/article/view/202/341
http://www.bjd-abcd.com/index.php/bjd/article/view/202/342
 
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Rights Copyright (c) 2016 British Journal of Diabetes
 

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