Is Apolipoprotein B and Small, Dense low density lipoprotein a better marker of cardiovascular risk?

International Journal of Biomedical Research

View Publication Info
 
 
Field Value
 
Title Is Apolipoprotein B and Small, Dense low density lipoprotein a better marker of cardiovascular risk?
 
Creator Abiodun, Ifeoluwa Silvanus; Babcock University Teaching Hospital, Ilishan-Remo, Ogun state, Nigeria
 
Subject Chemical Pathology
Cardiovascular diseases, Low density lipoprotein, Apolipoprotein B, Small dense loe density lipoprotein, high density lipoprotein, triglycerides, total cholesterol.
 
Description The association between low density lipoprotein cholesterol and cardiovascular risk is well established. However, the measurement of the cholesterol content of this lipoprotein incompletely accounts for the risk of cardiovascular disease. As part of its limitations, LDL cholesterol concentration does not precisely count the number of LDL particles, but Apo B does. The levels of Apolipoprotein B and small dense low density lipoprotein have been shown to be associated with risk of cardiovascular disease.. There is one Apo B per LDL particle, hence, LDL-Apo B accurately defines LDL particle number. Also, the ratio of cholesterol to Apo B differs from person to person, thereby explaining why LDL-cholesterol level does not necessarily indicate LDL particle number. Furthermore, Apo B reflects the concentration of potentially atherogenic particles i.e. the total Apo B level is a measure of the total number of lipoprotein particles in LDL, IDL and VLDL (non-HDL cholesterol). This implies that if most Apo B-containing lipoproteins in each fraction are atherogenic, the total concentration of Apo B will indicate cardiovascular risk better than LDL cholesterol level does. A predominance of small, dense, low-density lipoprotein cholesterol particles has been associated with a 3-fold or even greater risk of coronary heart disease in a collection of cross-sectional studies. Recent prospective evidence describes small, dense, low-density lipoprotein cholesterol as predictive of coronary heart disease as most of the traditional risk factors like smoking and elevated blood pressure. Cardiovascular risk is more directly related to the number and sizes of circulating atherogenic particles than to the concentration of cholesterol in these particles, therefore, adopting the traditional lipid profile (Triglyceride, HDL, LDL, total cholesterol etc.) will result in an underestimation of the true atherogenic burden as well as serve as a poor assessment of cardiovascular risk in individuals.
 
Publisher Scholar Science Journals
 
Contributor
 
Date 2015-10-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Review
 
Format application/pdf
 
Identifier http://ssjournals.com/index.php/ijbr/article/view/2638
10.7439/ijbr.v6i10.2638
 
Source International Journal of Biomedical Research; Vol 6, No 10 (2015): Oct; 775-779
0976-9633
2455-0566
 
Language eng
 
Relation http://ssjournals.com/index.php/ijbr/article/view/2638/1989
 
Rights Copyright (c) 2015 International Journal of Biomedical Research
http://creativecommons.org/licenses/by/4.0
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library