COMPUTER PROVIDING OF ACUTE TOXICITY OF DERIVATIVES 5-PHENETHYL-4-R-3-THIO(AMINO) 1,2,4-TRIAZOLE BY GUSAR-ONLINE

International Academy Journal Web of Scholar

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Title COMPUTER PROVIDING OF ACUTE TOXICITY OF DERIVATIVES 5-PHENETHYL-4-R-3-THIO(AMINO) 1,2,4-TRIAZOLE BY GUSAR-ONLINE
КОМП’ЮТЕРНЕ ПРОГНОЗУВАННЯ ГОСТРОЇ ТОКСИЧНОСТІ ПОХІДНИХ 5-ФЕНЕТИЛ-4-R-3-ТІО(АМІНО)-1,2,4-ТРІАЗОЛУ ЗАВДЯКИ GUSAR-ONLINE ПРОГНОЗУ
 
Creator Ignatova T. V.
Frolova Yu. S.
Kaplaushenko A. H.
 
Subject 1,2,4-triazole
GUSAR-online
acute toxicity
1,2,4-triazole
GUSAR-online
acute toxicity
 
Description An important step in the development of a new drug is the prediction of its toxicity by computer screening using the program GUSAR-online. The purpose of this work is an online prediction of acute toxicity among new derivatives of 5-phenethyl-4-R-3-thio(amino) 1,2,4-triazoles. Computer prediction of acute toxicity of 5-phenethyl-4-R-3-thio(amino)- 1,2,4-triazole derivatives was performed according to the structural formulas of the compounds in the online version of the GUSAR-online program.GUSAR-online prediction for 5-phenethyl-4-R-3-thio(amino)-1,2,4- triazole derivatives was performed during the research. It was found that the average lethal dose of LD50 is from 56.1 to 2396.0 mg / kg. Based on this, all compounds are low-toxic and virtually non-toxic substances.
An important step in the development of a new drug is the prediction of its toxicity by computer screening using the program GUSAR-online. The purpose of this work is an online prediction of acute toxicity among new derivatives of 5-phenethyl-4-R-3-thio(amino) 1,2,4-triazoles. Computer prediction of acute toxicity of 5-phenethyl-4-R-3-thio(amino)- 1,2,4-triazole derivatives was performed according to the structural formulas of the compounds in the online version of the GUSAR-online program.GUSAR-online prediction for 5-phenethyl-4-R-3-thio(amino)-1,2,4- triazole derivatives was performed during the research. It was found that the average lethal dose of LD50 is from 56.1 to 2396.0 mg / kg. Based on this, all compounds are low-toxic and virtually non-toxic substances.
 
Publisher RS Global Sp. z O.O.
 
Date 2020-09-14
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://rsglobal.pl/index.php/wos/article/view/1613
10.31435/rsglobal_wos/30092020/7185
 
Source International Academy Journal Web of Scholar; No 7(49) (2020): International Academy Journal Web of Scholar
International Academy Journal Web of Scholar; № 7(49) (2020): International Academy Journal Web of Scholar
2518-1688
2518-167X
 
Language eng
 
Relation https://rsglobal.pl/index.php/wos/article/view/1613/1530
 
Rights Copyright (c) 2020 Frolova Yu. S., Ignatova T. V., Kaplaushenko A. H.
https://creativecommons.org/licenses/by/4.0
 

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