Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report

International Journal of Clinical and Biomedical Research

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Field Value
 
Title Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report
 
Creator Chauhan, Rajkumar
Chadha, Pranav
Talapatra, Kaustav
Sen, Santanu
Tulpule, Sameer
Virkar, Mayuresh D.
Shrivastava, Amrita
Rodrigues, Reuben Jake
 
Subject Hematopoietic Stem Cell Transplantation; Graft-versus-Host Disease; Thalassemia Minor;
Radiotherapy; Myeloablative conditioning; Haemoglobinopathies
 
Description Background: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. Case presentation: A 2-year-old female child, diagnosed with TM was scheduled for haploidentical allogenic transplant-based protocol, and after that, based on protocol she was scheduled to undergo a single session of TBI as a conditioning regimen before haploidentical allogenic hematopoietic stem cell tranplant. A total dose of 4 Gy was administered.. The incidence of graft failure was reduced as TBI was used before allogeneic stem cell transplantation. TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. As it is comfortable for the patient to undergo, easily reproducible, and it helps to achieve a uniform dose distribution.
 
Publisher Sumathi Publications
 
Date 2020-10-29
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://www.ijcbr.com/index.php/ijcbr/article/view/373
10.31878/ijcbr.2020.64.06
 
Source International Journal of Clinical and Biomedical Research; Volume 6, Issue 4; October 2020.; 25-28
2395-0471
2521-0394
 
Language eng
 
Relation https://www.ijcbr.com/index.php/ijcbr/article/view/373/382
 
Rights Copyright (c) 2020 Mayuresh D. Virkar, Rajkumar Chauhan, Pranav Chadha, Kaustav Talapatra, Reuben Jake Rodrigues, Amrita Shrivastava, Santanu Sen, Sameer Tulpule
 

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