Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report

International Journal of Clinical and Biomedical Research

View Publication Info
Field Value
Title Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report
Creator Chauhan, Rajkumar
Chadha, Pranav
Talapatra, Kaustav
Sen, Santanu
Tulpule, Sameer
Virkar, Mayuresh D.
Shrivastava, Amrita
Rodrigues, Reuben Jake
Subject Hematopoietic Stem Cell Transplantation; Graft-versus-Host Disease; Thalassemia Minor;
Radiotherapy; Myeloablative conditioning; Haemoglobinopathies
Description Background: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. Case presentation: A 2-year-old female child, diagnosed with TM was scheduled for haploidentical allogenic transplant-based protocol, and after that, based on protocol she was scheduled to undergo a single session of TBI as a conditioning regimen before haploidentical allogenic hematopoietic stem cell tranplant. A total dose of 4 Gy was administered.. The incidence of graft failure was reduced as TBI was used before allogeneic stem cell transplantation. TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. As it is comfortable for the patient to undergo, easily reproducible, and it helps to achieve a uniform dose distribution.
Publisher Sumathi Publications
Date 2020-10-29
Type info:eu-repo/semantics/article
Format application/pdf
Source International Journal of Clinical and Biomedical Research; Volume 6, Issue 4; October 2020.; 25-28
Language eng
Rights Copyright (c) 2020 Mayuresh D. Virkar, Rajkumar Chauhan, Pranav Chadha, Kaustav Talapatra, Reuben Jake Rodrigues, Amrita Shrivastava, Santanu Sen, Sameer Tulpule

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us


Copyright © 2015-2018 Simon Fraser University Library