Plasma exchange in progressive systemic sclerosis

American Journal of Experimental and Clinical Research

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Field Value
Title Plasma exchange in progressive systemic sclerosis
Creator Owlia, Mohammad Bagher; Department of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Subject Medicine
Systemic sclerosis, plasma exchange, therapy, plasmapheresis, treatment

Description Systemic sclerosis (SSc) is an autoimmune systemic disease of unknown etiology. Present treatment modalities have limited impact on clinical/ laboratory outcomes. For the first time in our center, we used plasma exchange (PEx) in a rather young woman with recent onset but progressive SSc. She is a 39-year-old woman with a recent history of skin stiffness, Raynaud’s phenomenon, nail fold capillary changes and newly diagnosis of SSc presented to us due to worsening her clinical symptoms even after initiation of routine remedies such as low dose oral prednisolone, Ca-channel blockers, azathioprine and pentoxyfylline. After obtaining written consent, interdisciplinary discussion with experts in this field and agreement we started a series of plasma exchange with FFP replacement for her. A dramatic clinical response was observed in respect to Raynaud’s phenomenon, skin stiffness, tendon rub after three sessions of PEx. Her modified Rodnan skin score (MRSS) dropped from 36 (before commencement of therapy) to 28 in day 4 and 18 in day 20 after 15 sessions of PEx. In conclusion PEx could significantly modify the course of SSc as observed in our case study. Elimination of culprit immune mediators/cytokines/autoantibodies could be the possible mechanism of action of PEx. 
Publisher American Journal of Experimental & Clinical Research
Contributor None
Date 2015-10-12
Type info:eu-repo/semantics/article
Peer-reviewed Article

Format application/pdf
Source American Journal of Experimental and Clinical Research; Vol 2, No 4 (2015); 133-135
Language eng
Rights Authors who publish with the American Journal of Experimental and Clinical Resaerch (AJECR) agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

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