Development and Validation of New RP-HPLC Method For The Estimation of Voglibose In Bulk And Pharmaceutical Dosage Form

International Journal of Biomedical Research

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Title Development and Validation of New RP-HPLC Method For The Estimation of Voglibose In Bulk And Pharmaceutical Dosage Form
 
Creator Debnath, Royal
S. Y. , Manjunath
T, Hemant Kumar
 
Subject Voglibose; RP-HPLC; Method Development; ICH; Validation; Tablet dosage form
 
Description Background: Voglibose is used to lower blood glucose level in patients with Type 2 Diabetes Mellitus, especially when other medicines are not able to provide the desired results.
Aim and Objective: To develop and validate a simple, rapid, accurate and precise RP-HPLC method validated for the determination of Voglibose in table dosage form.
Materials and Method: Chromatographic analysis of the drug was achieved on C18 column (250 mm x 4.6 mm, 5 μm) as stationary phase with mobile phase consisting of acetonitrile and water in the ratio of 70: 30 v/v.
Results: The method showed a good linear response in the concentration range of 10-60 μg/ml with correlation coefficient of 0.999. The flow rate was maintained at 1.0 ml/min and detection was carried out at 214.5 nm. The retention time was 3.08 min. The method was statistically validated for accuracy, precision, linearity, ruggedness, robustness, solution stability, selectivity and sensitivity. The results obtained in the study were within the limits of ICH guidelines.
Conclusion: The method was found to be simple, sensitive and economical used for the determination of Voglibose in tablet formulation.
 
Publisher Scholar Science Journals
 
Date 2020-10-25
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://ssjournals.com/index.php/ijbr/article/view/5523
 
Source International Journal of Biomedical Research; Vol. 11 No. 10 (2020): Oct; e5523
0976-9633
2455-0566
 
Language eng
 
Relation https://ssjournals.com/index.php/ijbr/article/view/5523/3707
 
Rights Copyright (c) 2020 International Journal of Biomedical Research
http://creativecommons.org/licenses/by/4.0
 

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