Synthesis and Characterization of Herbal Nano-suspensions and Evaluation of their In-vivo Antihypertensive Potential with Especial Focus on Piperine

Journal of Pharmaceutical Research International

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Field Value
 
Title Synthesis and Characterization of Herbal Nano-suspensions and Evaluation of their In-vivo Antihypertensive Potential with Especial Focus on Piperine
 
Creator Murtaza, Arifa
Rehman, Tayyba
Zafar, Zohaib
Noreen, Safia
Iqbal, Mahwish
Hassan, Samia
Khawaish, Iqra
Tarar, Muhammad Haseeb Anwar
 
Description Poor aqueous solubility is the principle obstacle in accomplishing suitable oral bioavailability for huge proportion of drug composites in drug development todays. Nano-suspension is an emerging field of research in the scientific community to provide a new solution for poorly water-soluble active constituents. The objective of the nano-suspension is to reduce the drug particle size (100-200 nm) range, which enhance solubility and bioavailability of biopharmaceutical active compounds. Crude extract of Piper nigrum shows various biological activities but poor aqueous solubility so, there is a need to isolate the piperine from Piper nigrum and prepare its nano-suspension to reduce particle size and enhance its bioavailability. This review defines the principles behind nanosizing, the synthesis and characterization of piperine nano-suspension as well as the recent practice withapplication of such formulations in-vivo can be used as a better alternative to treat cardiovascular diseases with improved therapeutic efficacy compared to extract.
 
Publisher SCIENCEDOMAIN international
 
Date 2020-08-29
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://journaljpri.com/index.php/JPRI/article/view/30772
10.9734/jpri/2020/v32i2030772
 
Source Journal of Pharmaceutical Research International; 2020 - Volume 32 [Issue 20]; 202-215
2456-9119
 
Language eng
 
Relation http://journaljpri.com/index.php/JPRI/article/view/30772/57739
http://journaljpri.com/index.php/JPRI/article/view/30772/57740
 
Rights Copyright (c) 2020 © 2020 Murtaza et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
 

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