Dyslipidemia is the hallmark of the metabolic syndrome in postmenopausal women: Dyslipidemia in postmenopausal women

Annals of Medical Physiology

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Field Value
 
Title Dyslipidemia is the hallmark of the metabolic syndrome in postmenopausal women: Dyslipidemia in postmenopausal women
 
Creator Osman, Asim Alaaeldin
Fadlalla, Ahmed Mohamed
 
Subject Estrogen
Hyperlipidemia
Insulin resistance
Postmenopausal women
Estrogen
Hyperlipidemia
Insulin resistance
Postmenopausal women
 
Description The incidence of cardiovascular diseases (CVD) increases after menopause and may be due to changes in the plasma lipid-lipoprotein levels that occur following menopausal transition. Physiological estrogen withdrawal during menopause plays a major role in abnormal lipid metabolism such as elevated low-density lipoprotein concentration. The aim of this study was to determine the relationship between dyslipidemia and the causative factors of metabolic syndrome in postmenopausal women. In this cross-sectional study, 290 postmenopausal Sudanese women were included. Lipid profiles were measured by spectrophotometer, estrogen hormone determined by ELISA, insulin resistance determined by HOMA-2 calculator and lipid accumulation product was calculated by the following equation (waist circumference in cm X triglyceride concentration in mM). The results revealed that total cholesterol, triglycerides, low-density lipoprotein levels and very low-density lipoprotein levels were significantly higher in the postmenopausal women with metabolic syndrome (MS) in comparison to those without the MS. Elevated total cholesterol levels were seen in 51.7 %, elevated triglycerides were seen in 49.7% and elevated low-density lipoprotein levels were seen in 29.3% whereas reduced high density lipoprotein levels were seen in 16.89% of the postmenopausal women. Total cholesterol, triglycerides and very low-density lipoprotein values showed a significant positive correlation with insulin resistance and lipid accumulation and a significant negative correlation with the estrogen hormone level. In addition, high density lipoproteins showed a significant negative correlation with lipid accumulation levels.
 
Publisher Quench Academy of Medical Education and Research (QAMER) Publishing House
 
Date 2020-06-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed Article
text
 
Format application/pdf
text/xml
text/html
 
Identifier https://amphysiol.com/index.php/amp/article/view/v4i2.115684
10.23921/amp.2020v4i2.115684
 
Source Annals of Medical Physiology; Vol. 4 No. 2 (2020); 18-21
2456-8422
 
Language eng
 
Relation https://amphysiol.com/index.php/amp/article/view/v4i2.115684/2020_18_21.pdf
https://amphysiol.com/index.php/amp/article/view/v4i2.115684/2020_18_21.xml
https://amphysiol.com/index.php/amp/article/view/v4i2.115684/2020_18_21.html
 
Coverage worldwide
 
Rights Copyright (c) 2020 Quench Academy of Medical Education and Research (QAMER)
https://creativecommons.org/licenses/by/4.0
 

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