Gold nanoparticles delivery in mammalian live cells: a critical review

Nano Reviews & Experiments

View Publication Info
 
 
Field Value
 
Title Gold nanoparticles delivery in mammalian live cells: a critical review
 
Creator Lévy, Raphaël; University of Liverpool
Shaheen, Umbreen; University of Liverpool
Cesbron, Yann; University of Liverpool
Sée, Violaine; University of Liverpool
 
Subject
 
Description Functional nanomaterials have recently attracted strong interest from the biology community, not only as potential drug delivery vehicles or diagnostic tools, but also as optical nanomaterials. This is illustrated by the explosion of publications in the field with more than 2,000 publications in the last 2 years (4,000 papers since 2000; from ISI Web of Knowledge, ‘nanoparticle and cell’ hit). Such a publication boom in this novel interdisciplinary field has resulted in papers of unequal standard, partly because it is challenging to assemble the required expertise in chemistry, physics, and biology in a single team. As an extreme example, several papers published in physical chemistry journals claim intracellular delivery of nanoparticles, but show pictures of cells that are, to the expert biologist, evidently dead (and therefore permeable). To attain proper cellular applications using nanomaterials, it is critical not only to achieve efficient delivery in healthy cells, but also to control the intracellular availability and the fate of the nanomaterial. This is still an open challenge that will only be met by innovative delivery methods combined with rigorous and quantitative characterization of the uptake and the fate of the nanoparticles. This review mainly focuses on gold nanoparticles and discusses the various approaches to nanoparticle delivery, including surface chemical modifications and several methods used to facilitate cellular uptake and endosomal escape. We will also review the main detection methods and how their optimum use can inform about intracellular localization, efficiency of delivery, and integrity of the surface capping. Keywords: gold nanoparticles; cell delivery; bionanotechnology; nanomaterials; photothermal microscopy; cell imaging; intracellular fate (Published: 22 February 2010) Citation: Nano Reviews 2010, 1: 4889 - DOI: 10.3402/nano.v1i0.4889
 
Publisher Co-Action Publishing
 
Contributor
 
Date 2010-02-16
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
text/xml
 
Identifier http://www.nanoreviewsexperiments.net/index.php/nano/article/view/4889
10.3402/nr.v1i0.4889
 
Source Nano Reviews & Experiments; Vol 1 (2010) incl Supplements
2002-2727
 
Language eng
 
Relation http://www.nanoreviewsexperiments.net/index.php/nano/article/view/4889/5425
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/4889/5442
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/4889/5426
 

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