Octa-ammonium POSS-conjugated single-walled carbon nanotubes as vehicles for targeted delivery of paclitaxel

Nano Reviews & Experiments

View Publication Info
 
 
Field Value
 
Title Octa-ammonium POSS-conjugated single-walled carbon nanotubes as vehicles for targeted delivery of paclitaxel
 
Creator Naderi, Naghmeh
Madani, Seyed Y.
Mosahebi, Afshin
Seifalian, Alexander Marcus; University of College London
 
Subject carbon nanotube; drug delivery; nanotechnology
 
Description Background: Carbon nanotubes (CNTs) have unique physical and chemical properties. Furthermore, novel properties can be developed by attachment or encapsulation of functional groups. These unique properties facilitate the use of CNTs in drug delivery. We developed a new nanomedicine consisting of a nanocarrier, cell-targeting molecule, and chemotherapeutic drug and assessed its efficacy in vitro.Methods: The efficacy of a single-walled carbon nanotubes (SWCNTs)-based nanoconjugate system is assessed in the targeted delivery of paclitaxel (PTX) to cancer cells. SWCNTs were oxidized and reacted with octa-ammonium polyhedral oligomeric silsesquioxanes (octa-ammonium POSS) to render them biocompatible and water dispersable. The functionalized SWCNTs were loaded with PTX, a chemotherapeutic agent toxic to cancer cells, and Tn218 antibodies for cancer cell targeting. The nanohybrid composites were characterized with transmission electron microscopy (TEM), Fourier transform infrared (FTIR), and ultraviolet–visible–near-infrared (UV–Vis–NIR). Additionally, their cytotoxic effects on Colon cancer cell (HT-29) and Breast cancer cell (MCF-7) lines were assessed in vitro.Results: TEM, FTIR, and UV–Vis–NIR studies confirmed side-wall functionalization of SWCNT with COOH-groups, PTX, POSS, and antibodies. Increased cell death was observed with PTX–POSS–SWCNT, PTX–POSS–Ab–SWCNT, and free PTX compared to functionalized-SWCNT (f-SWCNT), POSS–SWCNT, and cell-only controls at 48 and 72 h time intervals in both cell lines. At all time intervals, there was no significant cell death in the POSS–SWCNT samples compared to cell-only controls.Conclusion: The PTX-based nanocomposites were shown to be as cytotoxic as free PTX. This important finding indicates successful release of PTX from the nanocomposites and further reiterates the potential of SWCNTs to deliver drugs directly to targeted cells and tissues.Keywords: carbon nanotube; drug delivery; nanotechnology(Published: 8 September 2015Responsible Editor: Russ Algar, The University of British Columbia, Vancouver, Canada.Citation: Nano Reviews 2015, 6: 28297 - http://dx.doi.org/10.3402/nano.v6.28297
 
Publisher Co-Action Publishing
 
Contributor
 
Date 2015-09-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
application/epub+zip
application/xml
 
Identifier http://www.nanoreviewsexperiments.net/index.php/nano/article/view/28297
10.3402/nr.v6.28297
 
Source Nano Reviews & Experiments; Vol 6 (2015) incl Supplements
2002-2727
 
Language eng
 
Relation http://www.nanoreviewsexperiments.net/index.php/nano/article/view/28297/42087
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/28297/42088
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/28297/42089
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/28297/42090
http://www.nanoreviewsexperiments.net/index.php/nano/article/downloadSuppFile/28297/21902
http://www.nanoreviewsexperiments.net/index.php/nano/article/downloadSuppFile/28297/22325
 
Rights Copyright (c) 2015 Alexander Marcus Seifalian
http://creativecommons.org/licenses/by-nc/4.0
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library