Nanometer resolution imaging by single molecule switching

Nano Reviews & Experiments

View Publication Info
 
 
Field Value
 
Title Nanometer resolution imaging by single molecule switching
 
Creator Hu, Dehong; Fundamental Science Directorate, Pacific Northwest National Laboratory
Orr, Galya
 
Subject
 
Description The fluorescence intensity of single molecules can change dramatically even under constant laser excitation. The phenomenon is frequently called as ‘blinking,’ and involves molecules switching between high- and low-intensity states (1). In addition to spontaneous blinking, the fluorescence of some special fluorophores, such as cyanine dyes and photoactivatable fluorescent proteins, can be switched on and off, by choice, using a second laser. Recent single-molecule spectroscopy investigations have shed light on mechanisms of single-molecule blinking and photoswitching. This ability to controllably switch single molecules led to the invention of a novel fluorescence microscopy with nanometer spatial resolution well beyond the diffraction limit.(Published: 2 April 2010)Citation: Nano Reviews 2010, 1: 5122 - DOI: 10.3402/nano.v1i0.5122
 
Publisher Co-Action Publishing
 
Contributor EMSL (A user facility of DOE-BER) and DOE-BES
 
Date 2010-04-02
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
text/xml
 
Identifier http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5122
10.3402/nr.v1i0.5122
 
Source Nano Reviews & Experiments; Vol 1 (2010) incl Supplements
2002-2727
 
Language eng
 
Relation http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5122/5536
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5122/5538
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5122/5537
 

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