Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)

Nano Reviews & Experiments

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Title Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
Creator Singh, Neenu; Institute of Life Science
Jenkins, Gareth J.S.
Asadi, Romisa
Doak, Shareen H.
Subject SPION, cellular stress, cytotoxicity, DNA damage
Description Superparamagnetic iron oxide nanoparticles (SPION) are being widely used for various biomedical applications, for example, magnetic resonance imaging, targeted delivery of drugs or genes, and in hyperthermia. Although, the potential benefits of SPION are considerable, there is a distinct need to identify any potential cellular damage associated with these nanoparticles. Besides focussing on cytotoxicity, the most commonly used determinant of toxicity as a result of exposure to SPION, this review also mentions the importance of studying the subtle cellular alterations in the form of DNA damage and oxidative stress. We review current studies and discuss how SPION, with or without different surface coating, may cause cellular perturbations including modulation of actin cytoskeleton, alteration in gene expression profiles, disturbance in iron homeostasis and altered cellular responses such as activation of signalling pathways and impairment of cell cycle regulation. The importance of protein-SPION interaction and various safety considerations relating to SPION exposure are also addressed. Keywords: SPION; cellular stress; cytotoxicity; DNA damage (Published: 21 September 2010) Citation: Nano Reviews 2010, 1: 5358 - DOI: 10.3402/nano.v1i0.5358
Publisher Co-Action Publishing
Date 2010-09-21
Type info:eu-repo/semantics/article

Format application/pdf
Identifier http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5358
Source Nano Reviews & Experiments; Vol 1 (2010) incl Supplements
Language eng
Relation http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5358/6030

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