Iron oxide based nanomagnet in nanomedicine: fabrication and applications

Nano Reviews & Experiments

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Field Value
 
Title Iron oxide based nanomagnet in nanomedicine: fabrication and applications
 
Creator Lin, Meng Meng; Keele University
Kim, Hyung-Hwan; Harvard Medical School
Kim, Hyuck; Jungwon University
Muhammed, Mamoun; Royal Institute of Technology (KTH)
Kim, Do Kyung; Keele University, Jungwon University
 
Subject
 
Description Iron oxide-based nanomagnets have attracted a great deal of attention in nanomedicine over the past decade. Down to the nanoscale, superparamagnetic iron oxide nanoparticles can only be magnetized in the presence of an external magnetic field, which makes them capable of forming stable colloids in a physio-biological medium. Their superparamagnetic property, together with other intrinsic properties, such as low cytotoxicity, colloidal stability, and bioactive molecule conjugation capability, makes such nanomagnets ideal in both in-vitro and in-vivo biomedical applications. In this review, a chemical, physical, and biological synthetic approach to prepare iron oxide-based nanomagnets with different physicochemical properties was illustrated and compared. The growing interest in iron oxide-based nanomagnets with multifunctionalities was explored in cancer diagnostics and treatment, focusing on their combined roles in a magnetic resonance contrast agent, hyperthermia, and magnetic force assisted drug delivery. Iron oxides as magnetic carriers in gene therapy were reviewed with a focus on the sophisticated design and construction of magnetic vectors. Finally, the iron oxide-based nanomagnet also represents a very promising tool in particle/cell interfacing in controlling cellular functionalities, such as adhesion, proliferation, differentiation, and cell patterning, in stem cell therapy and tissue engineering applications. Keywords: iron oxide; coprecipitation; thermal decomposition; microemulsion; magnetosome; lithography; cancer targeting; stem cell; gene delivery; tissue engineering; cell actuation (Published: 22 February 2010) Citation: Nano Reviews 2010, 1: 4883 - DOI: 10.3402/nano.v1i0.4883
 
Publisher Co-Action Publishing
 
Contributor
 
Date 2010-02-16
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
text/xml
 
Identifier http://www.nanoreviewsexperiments.net/index.php/nano/article/view/4883
10.3402/nr.v1i0.4883
 
Source Nano Reviews & Experiments; Vol 1 (2010) incl Supplements
2002-2727
 
Language eng
 
Relation http://www.nanoreviewsexperiments.net/index.php/nano/article/view/4883/5428
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/4883/5440
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/4883/5429
 

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