Engineering periplasmic ligand binding proteins as glucose nanosensors

Nano Reviews & Experiments

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Title Engineering periplasmic ligand binding proteins as glucose nanosensors
Creator Jeffery, Constance J.; University of Illinois at Chicago
Subject Biosensor; diabetes; periplasmic ligand binding protein; protein engineering; glucose binding protein
Description Diabetes affects over 100 million people worldwide. Better methods for monitoring blood glucose levels are needed for improving disease management. Several labs have previously made glucose nanosensors by modifying members of the periplasmic ligand binding protein superfamily. This minireview summarizes recent developments in constructing new versions of these proteins that are responsive within the physiological range of blood glucose levels, employ new reporter groups, and/or are more robust. These experiments are important steps in the development of novel proteins that have the characteristics needed for an implantable glucose nanosensor for diabetes management: specificity for glucose, rapid response, sensitivity within the physiological range of glucose concentrations, reproducibility, and robustness. Keywords: biosensor; glucose; diabetes; nanosensor; periplasmic ligand binding protein; protein design (Published: 19 January 2011) Citation: Nano Reviews 2011, 2: 5743 - DOI: 10.3402/nano.v2i0.5743
Publisher Co-Action Publishing
Contributor None
Date 2011-01-19
Type info:eu-repo/semantics/article

Format application/pdf
Source Nano Reviews & Experiments; Vol 2 (2011) incl Supplements
Language eng

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