Engineering periplasmic ligand binding proteins as glucose nanosensors

Nano Reviews & Experiments

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Field Value
 
Title Engineering periplasmic ligand binding proteins as glucose nanosensors
 
Creator Jeffery, Constance J.; University of Illinois at Chicago
 
Subject Biosensor; diabetes; periplasmic ligand binding protein; protein engineering; glucose binding protein
 
Description Diabetes affects over 100 million people worldwide. Better methods for monitoring blood glucose levels are needed for improving disease management. Several labs have previously made glucose nanosensors by modifying members of the periplasmic ligand binding protein superfamily. This minireview summarizes recent developments in constructing new versions of these proteins that are responsive within the physiological range of blood glucose levels, employ new reporter groups, and/or are more robust. These experiments are important steps in the development of novel proteins that have the characteristics needed for an implantable glucose nanosensor for diabetes management: specificity for glucose, rapid response, sensitivity within the physiological range of glucose concentrations, reproducibility, and robustness. Keywords: biosensor; glucose; diabetes; nanosensor; periplasmic ligand binding protein; protein design (Published: 19 January 2011) Citation: Nano Reviews 2011, 2: 5743 - DOI: 10.3402/nano.v2i0.5743
 
Publisher Co-Action Publishing
 
Contributor None
 
Date 2011-01-19
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
application/epub+zip
text/xml
 
Identifier http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5743
10.3402/nr.v2i0.5743
 
Source Nano Reviews & Experiments; Vol 2 (2011) incl Supplements
2002-2727
 
Language eng
 
Relation http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5743/6708
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5743/6710
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5743/7054
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5743/6709
 

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